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The role of generative AI tools in case-based learning and teaching evaluation of medical biochemistry | BMC Medical Education

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Consistency between the AI tool and the teachers’ comprehensive evaluation on the assignment evaluation results

By analyzing the homework scores of the two groups (Fig. 2A-D), we found that in the control group, there was no significant difference in homework scores between the comprehensive evaluation and the AI tool evaluation (P > 0.05). The same results existed for the experimental group. However, the task completion scores of the experimental group with the GAI tool were significantly higher than those of the control group (P < 0.05). This result indicates that the quality of the assignments with the AI tool is significantly higher than without the AI tool. However, based on the same grading rules, there is no statistically significant difference between the evaluation of the assignments by AI tools and the manual comprehensive evaluation, indicating that AI tools have the potential to replace the teacher’s evaluation of the assignments.

Fig. 2

A comparison of teacher and GAI tools in grading student assignments. S = Subjective evaluation, AI = AI evaluation. * P < 0.05; ** P < 0.01; *** P < 0.001; ns, no significance

The AI tool provides more detailed answers to case studies

We compared and analyzed the answers given by the control group and the experimental group to the two main clinical questions in the case, as shown in Table 2, and found that the experimental group gave more comprehensive and detailed answers. For example, for question 1 (What are the pathological and molecular mechanisms of hepatocellular carcinoma? ), the AI tool could not only give conventional answers, such as viral infection, cirrhosis, genetic factors, signaling pathway abnormalities, inflammatory microenvironment, etc., but also gave more cutting-edge answers. For example, tumor microenvironmental alterations, angiogenesis, epigenetic alterations, metabolic abnormalities and genomic instability. And in question 2 (What are the clinical and biological therapeutic options for the treatment of hepatocellular carcinoma? ) the AI tool also gave more specialized answers than the control group students. For example, in addition to the answers of surgical resection, liver transplantation, radiotherapy and chemotherapy, tumor vaccine, and immunosuppressant given by the control group, the AI group also gave more novel treatments, such as immune-combination therapy, neoadjuvant therapy, stem cell therapy, and multidisciplinary integrated therapy and postoperative follow-up. It can be seen that the AI tool cannot only provide more comprehensive answers, but also provide students with integrated basic and clinical knowledge by analyzing and integrating information through multiple data centers.

Table 2 Comparison between traditional retrieval methods and AI tools to answer case questions

AI tool reduces case study time and improves student test scores

AI software can quickly filter out content relevant to students’ needs from a large number of learning resources, helping students acquire the knowledge they need more quickly and reducing the time they spend sifting through massive amounts of information. When students encounter problems, AI can quickly give accurate answers and detailed explanations, saving students the time to find information and think on their own [16]. We investigated the time spent by students in completing the case discussion assignments through a questionnaire, and found that the average completion time of students in the experimental group was greatly reduced after the use of the AI tool, while the time used by the control group (t = 5.5 h) was significantly more than that of the experimental group (t = 2.6 h) (Fig. 3A). In addition, we also counted the number of times the control and experimental groups sought help from the instructor in completing their assignments, and found that the number of questions asked by the students in the experimental group (N = 10) decreased significantly compared to that of the control group (N = 35) after the use of the AI tool (Fig. 3B). All these results show that using AI tools speeds up students’ completion of assignments and saves more learning time. Meanwhile, we also analyzed the examination scores of the control group and the experimental group in the final examination (Fig. 3C). The results showed that the experimental group’s case study question scores (8.7 ± 2.1) and final exam scores (77.3 ± 4.3) were significantly higher than those of the control group ((6.4 ± 3.5; 66.5 ± 5.4) (P < 0.05). This indicates that AI tools can significantly enhance students’ understanding of clinical cases and improve their learning performance.

Fig. 3
figure 3

The influence of Kimi Chat 2.0 on students’ learning behavior. * P < 0.05; ** P < 0.01; *** P < 0.001; ns, no significance

AI tool has advantages in knowledge expansion of clinical cases

In this study, we investigated and analyzed the attitudes of students in the experimental group towards the role of AI tools in case study in biochemistry courses from positive and negative feedback (Fig. 4). The positive feedback questionnaire contained 12 questions, and all 39 questionnaires were collected through an online questionnaire, and the mean score (Mean ± SD) of the scores for each question was analyzed. The overall Cronbach’s α of the scale was 0.88, and the α coefficients of each dimension ranged from 0.74 to 0.85 with good reliability. Exploratory factor analysis extracted two common factors (cumulative explained variance 65.3%), and confirmatory factor analysis showed that the model fit well (CFI = 0.93, RMSEA = 0.07), supporting the preset structure.

Fig. 4
figure 4

The positive impact of Kimi Chat 2.0 on students’ learning outcomes

The questionnaire data analysis showed that in the first dimension (Q1-Q3), the means were Q1 = 9.50, Q2 = 7.14, and Q3 = 7.49, indicating that most students perceived AI tools as relatively easy to acquire and use. They also thought that AI tools could greatly save learning time and reduce the time spent on reviewing and translating literature, and it was easier to set the search content, which could easily realize human-machine dialogue. In the second dimension (Q4-Q6), we found that students highly agreed that AI tools played a complementary role to the textbook (Q4M = 9.18). Students also tended to agree that AI tools could provide them with a diversity of learning materials (Q5M = 6.47), whereas students did not agree that AI tools replaced existing e-learning resources (Q6M = 4.12). In the third dimension (Q7-Q9), the vast majority of students (Q7M = 8.48) were positive about the view that AI tools provide a more comprehensive explanation of basic knowledge. Most students also agreed that AI tools could expand biochemistry knowledge beyond the textbook (Q8M = 6.18). However, students’ agreement with the role of AI tools in the explanation of cutting-edge knowledge points was low (Q9M = 4.50). This also suggests that AI tools may have shortcomings in the tracking of new knowledge. In the fourth dimension (Q10-Q12), the view that AI tools are more comprehensive in analyzing cases was affirmed by most students (Q10M = 5.8), while more students believed that AI tools had limited role in deep understanding of clinical biochemistry in clinical cases (Q11M = 4.20). Most of the students did not think that the AI tool could generate similar clinical cases (Q12M = 3.90). This indicates that this AI tool has some limitations in generating complex concepts and cutting-edge knowledge.

Limitations of the AI tool in medical biochemistry case studies

Although AI tools have great potential in classroom teaching, we also need to be fully aware of their limitations and consider them carefully in their application to ensure that they are used sensibly, safely, and effectively. In this study, we also set six questions to investigate students’ attitudes toward the limitations of AI in biochemistry classroom teaching (Fig. 5). Most of the students believed that the use of AI tools reduced the interaction between students and teachers inside and outside the classroom (Q1M = 7.17), which was evidenced by the decreased frequency of students’ questions to the teacher. However, students were neutral in their views on whether AI tools reduced classroom attention (Q2M = 5.24). In addition, most students disagreed with the view that the use of AI tools reduces active thinking (Q3M = 4.31), and students were also neutral on the view that the use of AI tools reduces the training of creative thinking (Q4M = 5.5). Secondly, we also investigated the effect of AI tools on pressure to learning, and most students agreed that using AI tools increased the competitive pressure of learning (Q5M = 8.10) and led to homogenization of learning (Q6M = 6.56). This can be explained by the fact that the homogeneous answers provided by AI tools make the variability of scores among students not obvious. This is corroborated by the data from Fig. 3 of the experimental group’s homework scores.

Fig. 5
figure 5

The negative effects of Kimi Chat 2.0 on students’ learning

Evaluation of students’ attitudes towards the use of AI before and after the experiment

After the experiment, we investigated the opinions of the students in the experimental group on whether they agreed to use AI again. We found that the score of the students in the experimental group on their opinion of agreeing to use AI rose from 5.5 before the experiment to 7.6 (Fig. 6), and there was a significant difference between the two scores (P < 0.05). This indicates that the students in the experimental group did benefit from the use of AI, thereby changing their views on the use of AI in teaching.

Fig. 6
figure 6

The comparison of students’ attitude scores using Kimi chat2.0 before and after the experiment. * P < 0.05



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Education

First week ‘critical’ to avoid children missing school later, parents told

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Hazel ShearingEducation correspondent

Getty Images A stock image of two female primary school pupils, both in red cardigans, walking along a school corridor with their male teacher who is wearing a pink polo shirt and carrying a stack of pink notebooks.Getty Images

Pupils in England who missed school during the first week back in September 2024 were more likely to miss large parts during the rest of the year, figures suggest.

More than half (57%) of pupils who were partially absent in week one became “persistently absent” – missing at least 10% of school, according to government data first seen by the BBC.

By contrast, of pupils who fully attended the first week, 14% became persistently absent.

Education Secretary Bridget Phillipson said schools and parents should “double down” to get children in at the start of the 2025 term, which is this week for most English schools.

A head teachers’ union said more support was needed “outside of the school gates” to boost attendance.

Schools have always grappled with attendance issues, but they became much worse after the pandemic in 2020 and schools closed to most pupils during national lockdowns.

Attendance has improved since, but it remains a bigger problem than before Covid.

Overall, about 18% of pupils were persistently absent in the 2024-25 school year, down from a peak of 23% in 2021-22 but higher than the pre-Covid levels of about 11%.

The Department for Education (DfE) said the data from the first week of the 2024-25 school year showed the start of term was “critical” for tackling persistent absence.

Persistent absence in England falling but still high after pandemic. A bar chart shows the percentage of pupils missing at least 10% of school time by academic year. 2018-19: 11%, 2019-20 is missing because data was not published. This was the year where schools were affected by lockdowns from March onwards. 2020-21: 12%, 2021-22: 23%, 2022-23: 21%, 2023-24: 20%, 2024-25: 19%. Footnote: Non-attendance Due to Covid-19 is not included within absence rates for 2020-21 and 2021-22. The source is the Department for Education

Karl Stewart, head teacher at Shaftesbury Junior School in Leicester, said his school’s attendance rates were higher than average and but there was a “definite dip” in the two years after Covid.

“I get why. Some of that wasn’t necessarily parents not wanting to send them in. It was because either they had got Covid or other things, they were saying, ‘We’ll just keep them off now to be sure’,” he said.

The school has incentives like awards and class competitions to keep absence rates down, and Mr Stewart said attendance had more or less returned to pre-Covid levels.

“When we have the children in every day the results are just better,” he said.

“If you’re here, that gives you more time for your teacher to notice you, for us to see all that good behaviour [and] that really hard work – and that’s what we want.”

But, like lots of schools, he said some parents still took their children on unauthorised term-time holidays to make the most of cheaper costs.

Others, he said, have taken children for medical treatments overseas to avoid NHS waiting lists.

A photo of Karl Stewart stood outside his school in Leicester. He has short graying hair and is smiling at the camera, wearing a dark purple three-piece suit over a pink shirt and red tie. A rainbow is painted across the school building behind him as he leans against the railings on the pavement outside.

Head teacher Karl Stewart says results are “just better” for pupils with high attendance

The education secretary said that while attendance improved last year, absence levels “remain critically high, putting at risk the life chances of a whole generation of young people”.

“Every day of school missed is a day stolen from a child’s future,” Phillipson said.

“As the new term kicks off, we need schools and parents to double down on the energy, the drive and the relentlessness that’s already boosted the life chances of millions of children, to do the same for millions more.”

The DfE said 800 schools were set to be supported by regional school improvement teams – through attendance and behaviour hubs.

These hubs are made up of 90 exemplary schools which will offer support to improve struggling schools through training sessions, events and open days.

It said it had appointed the first 21 schools that will lead the programme.

However, Pepe Di’Iasio, general secretary of the Association of School and College Leaders, said attendance hubs were not a “silver bullet” and a more “strategic approach” was needed.

“I think the government has worked really hard to improve attendance and it continues to be a priority for them, but there’s certainly more to do,” he told the BBC.

“So many of the challenges that [school leaders] are facing come from beyond the school gates – children suffering with high levels of anxiety, issues around mental health.”

He said school leaders wanted quicker access to support for those pupils and specialist staff in schools, but pupils also needed “great role models” in the community through youth clubs and volunteer groups.

The Conservatives said Labour’s Schools Bill had dismantled a “system that has driven up standards for decades”.

Shadow education secretary Laura Trott said: “Behaviour and attendance are two of the biggest challenges facing schools and it’s about time the government acted.”

She added: “There must be clear consequences for poor behaviour not just to protect the pupils trying to learn, but to recognise when mainstream education isn’t the right setting for those causing disruption.”

Additional reporting by Nathan Standley



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AI in the classrooms: How Bangladeshi schools are adapting to a new digital era

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The recent explosion of Artificial Intelligence (AI) has pervaded numerous industries, going from a futuristic concept to an everyday reality. However, the impact of AI on schooling has been exceptionally staggering. 

From helping students complete assignments to reshaping the way teachers think about homework and exams, AI is beginning to redefine education all over the world. 

Bangladesh is no different.

Artificial Intelligence isn’t just coming to Bangladeshi classrooms—it’s already here. While its promise of convenience and quick solutions is quite alluring to students, the ever-growing presence of AI in schools has raised difficult questions: is learning actually taking place anymore or is it being replaced by answers generated not from thought, but from machines?

In schools across Bangladesh, AI tools like ChatGPT have quietly revolutionised how students complete their homework, how teachers prepare lessons, and how institutions rethink education altogether.

Is it a blessing or a bane? 

Students have quickly adapted to using advanced AI chatbots like ChatGPT, making AI an unavoidable and integral part of academic life. From essays to homework, students are increasingly finding ways to rely on AI not just to work faster, but to sidestep studying altogether.

Many schools and educators have now been forced to accept that resisting AI is no longer an option. Schools must adapt to the new reality or risk becoming redundant.

Yafa Rahman, Vice Principal and Senior Business Studies Teacher of Adroit International School, told The Business Standard, “Talks about integrating AI in the school curriculum is a global concern, and my school has had meetings with Pearson Education on how to do that in the best possible manner as well as train teachers to use AI in a beneficial way while being able to spot unethical AI use. This is an ongoing discussion, and we will see many changes soon.”

Yafa explained that her school also employs AI tools to structure assignments and class content. Rather than banning AI altogether, she believes in channelling students’ fascination with technology into meaningful learning. “Students rely on technology so much that if we incorporate any technology into the learning process, students instantly become more interested,” she said.

Rethinking the curriculum

The convenience of AI comes with a heavy cost. Teachers are reporting a surge in AI-generated assignments. Entire essays, reports, and even personal reflections are being turned in with no human touch. And it’s getting harder to spot the difference.

Educators have responded by rethinking the very structure of education in the country. Oral assessments, in-class essays, and presentations have become increasingly common, as schools seek to test students’ independent thinking rather than their ability to reproduce AI-generated answers.

“For assignments meant to show knowledge and understanding, I’ve returned to using pencil and paper to prevent AI use. For reflective assignments, I encourage students to use AI but remind them to think critically. You do not always have to agree with what AI generated, and key facts and figures must be checked with reliable sources,” said Olivier Gautheron, a Science Teacher at International School Dhaka (ISD) who has earned the “AI Essentials for Educators” certification from Edtech Teachers in the US.  

This hybrid approach reflects a wider consensus among educators that AI should not be ignored but incorporated responsibly, encouraging students to refine their critical faculties alongside their digital literacy.

It’s no longer just about stopping AI from being used. It’s about guiding how it’s used.

AI detection

Detecting AI-generated work isn’t straightforward. In universities, plagiarism software and AI detectors are standard. But in schools, teachers often rely on their personal knowledge of each student’s writing style and capability, using their instincts to identify when a student’s writing does not look like their own.

But Gautheron warns against over-reliance on intuition, preferring restraint over wrongful accusations.

“I believe it all comes down to knowing your students and their abilities,” he said. “There’s a high chance of mistakenly identifying student work as AI-generated when it’s not.”

He recalled an incident when he suspected a student of using AI, only to learn that the child had simply used software to improve grammar without altering the ideas. “This is perfectly acceptable, as the purpose of the assignment was for students to generate their own ideas,” he added.

He believes the solution lies not in advanced software but in dialogue. “Although software exists to detect AI, there are other softwares to make them undetectable. I believe that the best way to detect inappropriate use of AI is asking your students directly. If I feel that a student’s work quality is very different from previous tasks, simply asking them to clarify a few ideas of their work is enough.”

For resource-constrained schools, this approach is also pragmatic, since not every institution can afford detection software. 

AI for teachers

Just like students, teachers are also increasingly turning to AI for lesson planning and content creation

Emran Taher, Cambridge examiner and senior English instructor at Mastermind School, sees AI as a game-changer.

“It is not just the students who use AI. Teachers and schools are using it too. I can keep my syllabus up-to-date and incorporate more relevant topics and examples instead of just relying on textbooks. This helps grab students’ interest while reducing issues like bunking classes.”

He also uses AI for personalised instruction. By feeding student data—age, class level, strengths, and weaknesses—into AI tools, he receives tailored recommendations that help him address individual needs. “There are no bad students, only bad teachers,” he said. 

Striking the right balance

AI’s presence in schools reveals a tension: the same tool that can personalise learning and spark creativity can also be used to bypass real thinking. This balancing act between embracing innovation and preserving the essence of education appears to be the defining challenge of AI use.

However, there is no turning back. AI is already embedded in how schools operate. What matters now is how educators choose to respond. As Bangladeshi schools navigate this shift, teacher training, investment in digital infrastructure, and the development of ethical guidelines will all be crucial. 

Some see AI as a threat to academic honesty. Others see it as a catalyst for overdue change in the old, rigid education system. But everyone realises that the role of teachers must evolve to address the new digital landscape. 





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Education Ministry slammed for AI image of kids starting 1st grade

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The Education Ministry was panned across social media over the weekend for posting an AI image to Facebook on Friday of a fictional sextuplets ostensibly starting first grade, ahead of the start of the school year on September 1.

The ministry posted a picture of the six children standing in front of a school with the caption: “Next week we go back to school! In the meantime, meet the only sextuplets in the country who are entering first grade: Oren, Omer, Uri, Nadav, Dvir and Gil Orenstein.”

The post then quoted their fictional mother, Ilanit, as saying:  “I invested a lot in raising the children; it’s a great miracle that they were all born healthy. I took a two-year break from work to focus on raising the children and my husband was the sole breadwinner. I am the most excited in the world to see them grow up.”

No such sextuplets exist, and the photo was AI-generated. This fact was not initially made clear by the ministry. The post quickly drew a backlash on social media, with thousands of users slamming the ministry that is supposed to educate children for spreading a lie.

“One of your more embarrassing posts. The education system is collapsing, there are no teachers, no values, and schools are barely managing, and this is what you decide to post? A chauvinistic AI story about imaginary sextuplets with a mom who stays home and a father who supports them,” one person responded on Facebook, garnering 1,700 likes.

“Focus on improving education and not on degrading the conversation online,” she added.

Education Minister Yoav Kisch attends a meeting of the Knesset Education, Culture, and Sports Committee in Jerusalem, May 12, 2025. (Yonatan Sindel/Flash90)

Another commenter said the post was “absurd,” and “typical of the lazy and spineless” Education Minister Yoav Kisch, saying that “these are his values ​​and what he promotes before the start of the school year.”

One commenter said that they asked ChatGPT what it thought of the post, saying that the AI chatbot said it was “highly problematic, especially coming from the Education Ministry.”

“The post undermines public trust [in the ministry], and trust is the foundation of the education system,” ChatGPT added, according to the commenter.

“This is the page that represents the places to which you send your children,” said another poster. “Time to consider homeschooling.”

The ministry later defended the upload, responding in a comment to its original post: “Okay, we admit these sextuplets are not really on the way to first grade, the photo was created with AI.

“We wanted to open the school year with a smile and to remind you that just like in school, on the web we also need to stop, check, and use our critical thinking,” it asserted.

“Wishing everyone a curious, fun school year full of good surprises,” its second post said.

Illustrative photo of students on the first day of school, at the Gabrieli Carmel School in Tel Aviv, on September 1, 2024. (Avshalom Sassoni/Flash90)

The Education Ministry under Kisch has undergone a tumultuous year, which included several teacher strikes, budget issues and a controversial change to public school curriculum, which mandated an hour of bible study each week for all students in first to twelfth grade, as well as additional mandatory classes on Zionism and “Israel’s wars and rebirth.”

Schools will also be required to bring students on tours of Jerusalem and Jewish heritage sites around the country, with an emphasis on sites in the West Bank.


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