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Surgeons transplant pig lung into brain dead human recipient for first time | Medical research

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Surgeons have transplanted a lung from a genetically modified pig into a brain dead human recipient for the first time and found it functioned for nine days, researchers have revealed.

The work is the latest development in a technique called xenotransplantation that is aimed at solving the organ shortage crisis: according to the World Health Organization, only up to 10% of the global need for such transplants is being met.

However, experts have stressed there is a long way to go before pig lungs can be used in patients.

Dr Justin Chan, a lung transplant surgeon for the NYU Langone Transplant Institute who was not involved in the work, described the study as “exciting and promising work”, but said the report concerned only one patient and was a “qualified success”.

“These lungs are not able to independently sustain a patient,” he added.

Andrew Fisher, a professor of respiratory transplant medicine at Newcastle University, agreed. “This work is very welcome in furthering our understanding, but it marks an incremental step forward. There is much more work required and we are not on the dawn of an era of lung xenotransplantation using pig lungs,” he said.

Xenotransplantation has become a hot area of research in recent years, with the heart, kidneys and liver among the organs that have been transplanted into humans from pigs. The latter are typically genetically modified by removing certain pig genes and inserting specific human genes, to reduce rejection of the organs by the recipient’s body.

Studies are often initially carried out on brain dead human recipients before, in some cases, being used in living patients. While there have been only a handful of living recipients, many have died within weeks or months of such surgery, albeit not necessarily from complications relating to the transplant. However, some with transplanted pig kidneys have survived with the organs still functioning several months after the procedure.

But experts say xenotransplantation using lungs is particularly tricky.

“Every breath you breathe in is bringing the external environment into the body,” said Fisher. This means the lungs need to be very capable of responding to attacks from pollution, infection and other sources. “So the immune system in the lung is very sensitive and very active, which means when you’re dealing with organ transplantation, where you know you don’t want the immune system to be very active, it poses extra challenges.”

Writing in the journal Nature Medicine, researchers in China reported how they transplanted the left lung from a Chinese Bama Xiang donor pig with six genetic modifications into a 39-year-old brain dead male recipient.

The team found the lung remained viable and functional over a 216-hour period and did not trigger hyperacute rejection – a rapid, violent immune response by the recipient’s body. There were also no signs of infection.

However, 24 hours after transplantation the lung showed signs of fluid accumulation and damage, possibly initially due to transplant-related inflammation. And despite the recipient being given powerful immunosuppressive medication, the transplanted organ was progressively attacked by antibodies, resulting in significant damage over time.

“The impact of the damage was likely underestimated [because] the human recipient still had one of their own lungs present and this would have compensated for the damaged porcine lung,” said Fisher.

Prof Peter Friend, from the University of Oxford, said the results were complicated by the fact brain death itself causes an acute inflammatory state. “So some of what they are seeing may be a function of the brain dead status of the recipient,” he said.

The researchers behind the work said the approach needed to be refined.

“Continued efforts are needed to optimise immunosuppressive regimens, refine genetic modifications, enhance lung preservation strategies and assess long-term graft function beyond the acute phase,” they wrote.

Friend said other approaches to increasing the availability of organs were being investigated, including remodelling donor organs using stem cells.

Some research groups are also exploring the possibility of growing humanised organs inside pigs or sheep.

Fisher added that while xenotransplantation for lungs held promise, another promising avenue was to treat human donor lungs deemed to be unsuitable for transplantation so they could be used.

“If we get that right, that’s something can be implemented within months, and certainly in years could be making very big differences,” he said.



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Indonesia protests: Prabowo makes concessions after days of deadly protests forced him to scrap China summit trip

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Jakarta
Reuters
 — 

Indonesian political parties have agreed to cut lawmakers’ benefits, President Prabowo Subianto said on Sunday, in a bid to calm anti-government protests that have killed at least five people in the country’s worst violence in decades.

Protests began on Monday over what demonstrators called excessive pay and housing allowances for parliamentarians, escalating into riots on Friday after a motorcycle rideshare driver was killed during police action at a protest site.

Homes of political party members and state buildings were ransacked or set ablaze, shaking investor confidence in the Southeast Asian economy and triggering a steep selloff on its stocks and currency markets on Friday.

Looters broke into a house owned by Finance Minister Sri Mulyani Indrawati outside the capital Jakarta overnight, state news agency Antara reported on Sunday. She was not in the house at the time and it was not clear if she uses the property often.

More protests are planned for Monday, and student groups did not call them off after Prabowo’s announcement.

Prabowo, speaking at a press conference at the Presidential Palace and flanked by the leaders of various political parties, said he had ordered the military and police to take stern action against rioters and looters. He said some of the unrest bore the signs of terrorism and treason.

“Leaders in parliament have conveyed that they will revoke a number of parliament policies, including the size of allowances for members of parliament and a moratorium on overseas work trips,” Prabowo said.

“To the police and the military, I have ordered them to take action as firm as possible against the destruction of public facilities, looting at homes of individuals and economic centers, according to the laws,” he added.

The protests represent the most significant challenge yet to Prabowo’s government, which has faced little political opposition since taking office nearly a year ago.

Prabowo, who canceled a high-profile trip to China due to the unrest, also met on Sunday with key members of his cabinet at the Presidential Palace to discuss the situation.

Many ministers and political leaders arriving at the palace used civilian number plates instead of special ones given to officials, a witness said, in an apparent security measure as unrest simmered in some places.

The military was deployed to guard the palace on top of the usual secret service detail. Many key ministers’ homes and government installations were also being guarded by the military on Sunday.

It remains unclear who is behind the rioting and looting that followed the protests, which were initially organized by student associations.

Muzammil Ihsan, head of the All Indonesian Students’ Executives Body, the country’s largest student umbrella group, told Reuters cutting lawmakers’ perks was “not enough” and said further demonstrations were being “considered.”

“The government must resolve deep-rooted problems. The anger on the streets is not without cause,” Ihsan said.

Tegar Afriansyah, the chairman of a smaller student group, Indonesian Student League for Democracy, which has been protesting since Monday, said the presidential announcement does not address the root of the problem, which is “political oligarchy and an unequal economic structure.”

He termed Prabowo’s instructions to police and military as “clearly repressive and intimidating.”

Global rights watchdog Amnesty International’s Indonesia chapter in a statement termed Prabowo’s use of terms such as treason and terrorism as “excessive.”

TikTok, owned by China’s ByteDance, said it had suspended its live feature in Indonesia for a few days.

The death toll rose to five on Sunday, according to the local disaster management agency in Makassar, South Sulawesi province. It said an online motorcycle taxi driver was beaten to death by a mob accusing him of being an intelligence agent.

Three others were killed in an arson attack on the local parliament building on Friday.





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‘Rock of Love’ Star Kelsey Bateman Dead at 39

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‘Rock of Love’
Kelsey Bateman Dead at 39 …
Starred on Season 3 of Reality Show

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Notre Dame vs. Miami live updates: Carson Beck leads Hurricanes into battle with Irish in top-10 showdown

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No. 6 Notre Dame and No. 10 Miami are set for a Sunday night showdown as college football’s Labor Day weekend marathon continue with a seismic clash between two iconic brands. It will mark just the fifth meeting since 1990 — and first since 2017 — between a pair of storied programs with lofty 2025 aspirations.

The Fighting Irish are coming off an appearance in the 2025 CFP National Championship and boast an elite running back tandem and loaded defense. Miami, now in Year 4 under coach Mario Cristobal, appears to have amassed the talent and physicality needed to break through after it was was left just outside of the 12-team CFP last season.

But now it’s time to show it on the field, and there are questions for both teams to answer, particularly at quarterback. Notre Dame is turning to redshirt freshman CJ Carr, the grandson of legendary former Michigan coach Lloyd Carr. Miami is going with Carson Beck, the Georgia transfer who is coming off surgery on his throwing elbow.

The winner will earn a leg up in the CFP race while the loser will see their margin for error shrink with a long season still ahead.

Keep it locked here as CBS Sports provides you with live updates, highlights and analysis as LSU battles Clemson to open the 2025 season in Week 1. 





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