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‘Smart Businesses Are Going to Maintain Flexibility’

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ADI IGNATIUS: I’m Adi Ignatius.

ALISON BEARD: I’m Alison Beard, and this is the HBR IdeaCast.

ADI IGNATIUS: Alison, I know we talk a lot about how difficult it is these days to be a business leader, and I’m interested: in your conversations, what do you think is top of mind for business executives who are trying to manage these very uncertain times?

ALISON BEARD: That is a good question because there are so many different things right now. I would certainly say shifting economic policies, artificial intelligence has to be incredibly high on the list – how to harness GenAI and agentic AI for the best use, and not be disrupted by it. And then geopolitical instability in Europe and the Middle East. I think there are plenty of things to keep CEOs up at night right now.

ADI IGNATIUS: Yeah, so it feels like an unprecedented level of uncertainty. At the same time, there’s a playbook for uncertainty and there are people who have something to say about how to manage a company when things are as uncertain as they are in all the areas you talked about.

So today’s guest is somebody who I think can really talk at all levels, about how to think through all these challenging issues, but also how to cope, how to manage the uncertainty in your own company. And that is that is Larry Summers, former treasury secretary, former president of Harvard University, and an economist who is just generally well-respected.

ALISON BEARD: He’s certainly someone that can connect all those dots I just talked about. He’s also currently on the board of OpenAI, so I’m very interested to hear what advice he has.

ADI IGNATIUS: You know, businesses can’t wait for these things to be resolved. Many of them will never be resolved. So I think there’s some insights here into how to move forward, how to take action. I spoke to him as part of our new HBR Executive Live series, and we decided to open this one up to the broader IdeaCast audience. So I hope you enjoy it. This is my interview with Larry Summers.

You’re a guy who is much in demand, I would think, particularly in an era where we’re just dealing with what feel like unprecedented levels of uncertainty, unprecedented shocks to the system. And I want to talk about a few of them, but maybe start with tariffs. A couple months ago, tariffs were all we could talk about. There’s been a bit of a lull as the negotiations play out. How do you see things playing out and what should business even be rooting for at this point?

LAWRENCE H. SUMMERS: Look, this is mostly a self-inflicted wound to the American economy. It simultaneously raises prices and increases unemployment, and for most industries, reduces competitiveness because it raises the price of inputs. For example, 60 times as many people work in industries that use steel as work in the steel industry. It’s not surprising that the Fed has done something over the last six months that’s very rare for it, and raised its forecast of inflation, that at the same time it was also raising its forecast of unemployment.

I think it’s pretty clear that these policies are a mistake. They’re not going to make American businesses substantially more competitive in aggregate. They’re unlikely to have a large favorable impact on the trade deficit. They’re going to alienate other countries who are going to, at least some cases, retaliate against the United States, and I think they’re going to be a strategic gift to China. It can’t be the right thing for the United States to do, to be raising tariffs back most of the way to the Smoot-Hawley level. And given the extremity of the statements that were made on “Liberation Day,” that’s about what we are doing.

Now all of that said, I think that businesses are ultimately judged, not on tariffs, but on the products they produce. And there are many products that many American companies produce, for which there has been and will continue to be very strong global demand. So to say that these are unwise policies, is not at all to say that all businesses should hunker down and go into a shell because of these policies.

ADI IGNATIUS: One of the other questions though is, are these even real? I mean, to what extent as America leans forward the threat of high tariff rates, is this a negotiating ploy? Does it fundamentally reset trade? And how is business supposed to deal with that level of uncertainty when it’s not clear? We have to make economic decisions, do we invest, do we change our supply chain? But we’re not really sure where this ends up, this complete lack of certainty.

LAWRENCE H. SUMMERS: Look, I think smart businesses are going to maintain flexibility and have robust strategies that work at least reasonably well in a variety of different environments. In round numbers, tariffs were about one and a half percent on average when the president took office in 2016. During his first term, tariffs went up from one and a half percent to a little bit below 3%. On “Liberation Day,” they were raised up to 28%. And I think most people now expect that they’ll settle at 13 or 14% as an average tariff rate.

So I don’t think there’s any serious question that the United States is engaging and will after all the negotiations have lifted tariffs in a very substantial way. So I think people should just build that into their planning. That said, there’s still going to be substantial doubt depending on what your industry is in, just what rules there will be. There also is uncertainty about what concessions will be extracted from other countries, which for some businesses, will affect export opportunities.

ADI IGNATIUS: Yeah. Well, so that maybe leads to a more short-term question, which is, are we headed toward a recession in 2025? I’d be interested in your response, but also what are the indicators you’re most focused on as you think about that question?

LAWRENCE H. SUMMERS: I think that right now you would say that there was a real risk of recession, but I think you would say that it was less than 50/50. I’d pay a lot of attention to divergences between sentiment measures: business confidence, consumer confidence, and hard data: same store sales, industrial production last month. There has been over the last several months, a divergence with sentiment being substantially negative and the hard data being firmer. I would say the indications most recently are of sentiment getting better, rather than of the hard data deteriorating sharply.

And so my best guess is that you’re not going to see, barring further dramatic events, a substantial turn down in the economy. I am more worried that as the tariffs feed through, which they surely will, that you’ll see some increment to inflation. And given that we’ve just been through a difficult inflationary period, that may translate into higher inflation expectations.

ADI IGNATIUS: So what explains the improvement in sentiment? I’m not sure what that measures exactly, but does that mean there’s less panic about the uncertainty? There’s less concern about how tariffs will ripple through the economy. I mean, what does that mean?

LAWRENCE H. SUMMERS: Adi, I think there were a number of indicators of shoes that could have dropped, that haven’t. A big shoe could have dropped on inflation spiking. A big shoe could have dropped on the bond market sending interest rates to the sky. A big shoe could have dropped on a major air pocket after tariffs were imposed, because people had bought in advance of the tariffs, sort of hoarding ahead of the price increase.

And so when none of those shoes dropped in a huge way, I think people are feeling a bit better. We’re certainly not out of the woods and especially not out of the woods, given that there’s a lot of geopolitical uncertainty and frankly, given that the president’s behavior is somewhat unpredictable. But I think a fair-minded person would have to say you haven’t seen some of the most alarmist scenarios play out. And as they don’t play out, people become a little bit more confident.

ADI IGNATIUS: So on this topic, this is a question from one of our subscribers, Paul. I don’t know where Paul’s writing from, but question, how do you think about the inverted yield curve as a potential recession predictor?

LAWRENCE H. SUMMERS: The yield curves had a pretty good track record, but the yield curve is really a tracker based on the idea that if we have a recession, the Fed cuts rates. And if people think the Fed’s going to cut rates, then maybe that means they’re thinking that there’s going to be a recession and markets are relatively efficient. I think you’ve got some different factors going right now, given that you’ve got a president who’s very worried about the capital inflows associated with the trade deficit, given that the long run fiscal picture appears relatively problematic. It’s a thing that I would pay attention to, but it’s probably not the thing that I would be most focused on.

I don’t think that anybody thinks that the yield curve has a causal impact on the economy turning down. It’s an indicator of what people think the Fed’s going to do, and what people think the Fed’s going to do is with what they think the Fed’s going to be responding to in the economy. But I wouldn’t overplay its prediction power.

ADI IGNATIUS: So you mentioned China earlier, and when you’re talking about shoes that could drop, that could have significant impact on everything we’re talking about. It could be a real rupture, a deeper rupture in the economic relationship that the US has with China. I suppose on the flip side, a shoe that could drop would be a much improved relationship.

In your mind, and I don’t know how much you think about this, is there a plausible deal that the US could do with China, or an understanding we could reach with China that would be meaningful to both sides?

LAWRENCE H. SUMMERS: I think it’s going to be pretty difficult, given the degree of distrust on both sides. But if there was a sense that they were not going to use rare earths as a tool of course, of diplomacy, vis-a-vis us, and that we were not going to restrict the flow of chips and other technologies to them beyond the stuff that was most specifically targeted on national security, I think that would probably be a constructive agreement that would help to rebuild trust to some degree. So I think that this isn’t a matter of having one mega agreement and then it’s all better. It’s a matter of having a series of trust building, bits of cooperation that work out to be mutually beneficial and that are then built upon.

ADI IGNATIUS: You know, you’ve been critical of the Trump administration. And on the flip side, I was talking to a Silicon Valley CEO the other day who said in his view, his circle, he said, “You have to understand this group was sort of deep blue, politically, liberal, pro-democratic politically, and they sort of flipped to deep red. Really making the case that the Democrats lost business through perceived excessive regulation, other restraints.

I have a couple of questions here, but is anyone articulating in appealing economic middle ground that isn’t trade war, tariffs everywhere, but isn’t a kind of high regulation approach that caused that flip for a lot of business people?

LAWRENCE H. SUMMERS: There have been a number of ideas that have been put forward. I think a phrase that’s been used a lot after a book by Ezra Klein and Derek Thompson, is the Abundance agenda. I think that anybody sensible should think in addition to allocating money to infrastructure, we just need to figure out as a country how to get it done faster and more efficiently.

I like to tell the story of the bridge from Harvard Square across the Charles River to the Harvard Business School, that bridge is 362 feet long. It had a lane of traffic closed for 62 months, that’s 50% longer than it took the United States to win World War II, just to fix a bridge. And I did some research on it. There’s a bridge across the Rhine. The Rhine isn’t 362 feet across. It’s 3,600 feet across, and Patton built a bridge across it from nothing in one day. And perhaps even more striking, Julius Caesar, who didn’t have any of the modern tools that we have today, built a bridge across that 3,600 feet in nine days, and yet it takes contemporary America 62 months.

That’s not an isolated example. The Second Avenue Subway in New York cost about 12 times as much as a comparable length subway put in two countries that we don’t usually think of as paragons of efficiency, Paris, France and Ankara, Turkey. –

So I think there’s a lot that we need to do to loosen things up. I think it’s very important not to practice the politics of envy. Yes, everybody should pay their fair share and the fair share of people who’ve been more fortunate should be higher than the fair share of people who’ve been less fortunate. But that’s not to say that there’s something evil about being rich or that our goals should be for everybody to earn the same income. I like to ask people the question, would America be a better country if there were more success stories like Bill Gates and Steve Jobs and Jeff Bezos, or would it be less successful?

I think it’s pretty clear that it would be more successful. It’d be better. There’d be more jobs for workers. There’d be better opportunities for consumers. America would be standing taller in the world. But it is true that if we had more great entrepreneurs, we’d have more great fortunes. I think that is fine. But I think when too many in the Democratic Party treated any huge success as ground for protest. So I think it’s very important to recognize that there can’t be employees without employers, and therefore for those of us who are progressive, to maintain a pro-responsible business sensibility.

And I certainly do think there have been moments when the Democratic Party lost sight of that, and put an overwhelming emphasis on values associated with culture and identity politics, or put great emphasis on tearing down the rich rather than on building up the middle class.

ADI IGNATIUS: Okay. So let’s talk about labor then more directly. And this is a question from Maureen from somewhere or another. What is your view, let’s say on the US labor market, what should employers in particular be watching most closely as they think about the labor input?

LAWRENCE H. SUMMERS: I think we have done poorly as a country with the half of our population, probably the 60% of our male population that really isn’t oriented to going to college. And that wants to participate in a variety of kind of trade activities, often providing services that are in extremely short supply. I think our institutions and our educational system has been shaped somewhat more by the Harvards and by the institutions that want to emulate the Harvards, and I’m not sure that they are appropriately attentive to the needs of many, many of our people who want to learn a set of skills for which they can be rewarded in a substantial and secure way.

So I think that our educational system, particularly with a view to those going into non-academic paths, is something that deserves a great deal of attention. I think we need to find models of more cooperative unionism. I think we’ve had some serious issues in our country, where without unions, labor frankly has been exploited excessively for the benefit of capitalists. But we also have situations as in the education sector. And as years ago was the case in the automobile sector, where strong unions made it very, very difficult for enterprises to produce as productively as they otherwise could.

ADI IGNATIUS: I’m interested, I guess, in your experience in talking to business leaders, I assume you’re talking to a lot of them right now. We launched this whole thing, HBR Executive because we felt that we’re leaning into a moment of real uncertainty. And I think it comes from two main areas. I think artificial intelligence, which is likely to remake most of our businesses, but we’re not sure when and to what extent. And then the political and geopolitical uncertainty. So I guess I’m interested, when you talk to business leaders, are those the issues they’re most concerned about or is it something else that we need to pay attention to?

LAWRENCE H. SUMMERS: I think that it’s very often that… In general, it was my experience when I worked in Washington, that if I got to know a business leader too well, it would probably be a good time to short the company. That there are a lot of business leaders who… And some of this is clearly important and the right thing to do, involve themselves extensively in public policy. That’s right, and it can be very important for business, but it’s also very important to produce a good product efficiently.

I always think of a quintessentially cautionary tale for business leaders. In the early 90s, the CEO of Kodak spent a great deal of time in Washington, pushing the US government to pursue various kinds of antitrust and competition policy related actions, directed at opening up the market in Japan for Kodak to compete with Fujifilm. And certainly some of the arguments being made were legitimate. I don’t think Kodak was being treated fully fairly in Japan. But I can’t help but wonder whether it would’ve been a much better use of that CEO’s time, to focus on the overwhelming strength that Kodak had in digital photography patents, strength that it never successfully exploited.

And so I would urge business leaders in general, in any environment and certainly in this one, to focus on what is the distinctive strength that my business has. And in a world where there’s going to be more and more division of labor, how can we focus the most on that distinctive strength so as to deliver value for all our different constituencies.

ADI IGNATIUS: Let’s talk more about AI specifically. We all have an opinion. We all probably have a strong opinion on AI and what it’s going to do. I interviewed one of your colleagues, Karim Lakhani from Harvard Business School, who’s an expert on AI in the workforce. And his view is that AI is not being over hyped, probably the opposite. That CEOs talk a lot about it, they talk to their boards about it, they talk to their shareholders about it, they don’t really know what’s going on. They’re not getting their hands dirty, they don’t understand the revolution that is taking place. I’m interested in your view, you probably have a view, you’re probably talking to experts as well. Do you see AI, GenAI as kind of fundamentally reshaping the economy, or are you more cautious about that?

LAWRENCE H. SUMMERS: I think there’s a better than even chance that this is the most important technical change, or the most important change in technology in my lifetime. That it’s going to change more about the way people live and the way people work, than anything else that has happened during my adult lifetime. I think it’s very hard to know exactly what the timeframe will be. I think it’s very hard to know exactly what the changes will be.

But we haven’t had a technology that is self-improving before, ever. PCs don’t make new, better PCs, but AI models have the capacity to what one might call the recursive aspect, to figure out how to be self-improving. In the same way that human societies acting together have the way to be self-improving. And so I think that capacity for self-improvement is something that’s very fundamental. Now how much it’s going to change in terms of regular day-to-day business interactions, in what timeframe? I think that’s a much more difficult thing to judge, and I think that it is often the case in these things that it’s not best to be a first mover. It’s best to hang back a little bit and see what works and see what doesn’t, before making large CapEx commitments. But I think ultimately, this is going to be a pretty big deal.

ADI IGNATIUS: Larry, I want to thank you. This has been an amazing conversation. Thank you very much for being with us.

LAWRENCE H. SUMMERS: Thank you.

ADI IGNATIUS: That was former Treasury Secretary Larry Summers. He spoke to me as part of our HBR Executive package for senior organizational leaders. You can learn more at HBR.org/executive.

Next week Alison will talk about how to build your own AI assistant, in a conversation with Alexandra Samuel. We now have more than a thousand IdeaCast episodes, plus many more HBR podcasts to help you manage your team, your organization, and your career. Find them at hbr.org/podcasts or search HBR in Apple Podcasts, Spotify, or wherever you listen.

Thanks to our team, senior producer Mary Dew, associate producer Hannah Bates, audio product manager Ian Fox, and senior production specialist Rob Eckhardt. And thanks to you for listening to the HBR IdeaCast. We will be back with a new episode on Tuesday. I’m Adi Ignatius.



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Roche’s Chugai Breaks Into Aging via Potential $1B+ Deal With AI Outfit Gero

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Tokyo-based Chugai Pharmaceutical is joining with the AI-driven biotech Gero, in a research collaboration on age-related diseases potentially worth more than $1 billion.

The collaboration will see Chugai, majority owned by Roche, creating novel antibody drug candidates using its in-house engineering capabilities. The targets sought by those antibodies will be discovered using Gero’s AI target discovery platform, which serves as predictive models of human health trained on longitudinal medical records. Chugai will get exclusive worldwide rights to any drug candidates made in the collaboration.

Under terms of the deal, Chugai will make an undisclosed upfront payment and put up approximately $250 million if certain unannounced development or sales milestones are reached. If Chugai successfully launches a product, the company will pay Gero additional royalties, which could push the total value of the deal to above $1 billion, according to an email sent to BioSpace from a Chugai representative.

Though the companies did not announce any specific indications they will be targeting in the collaboration, Singapore-based Gero’s stated cause is to eliminate the “root causes of age-related diseases.”

“Our AI platform is built to identify therapeutic targets that drive multiple age-related diseases and potentially aging itself,” Gero CEO Peter Fedichev said in a statement. “In this collaboration, we aim to translate those insights into therapeutics that can help restore the lost function. This partnership with Chugai is an important step toward achieving Gero’s mission: to meaningfully target the biological processes of human aging.”

Gero previously inked a deal with Pfizer in January 2023 to apply its AI technology platform to discover targets in fibrotic diseases. Financial terms of that deal were not disclosed, only that Gero would receive an upfront payment and be eligible to receive discovery milestone payments. Gero appears to still be in its early stages, having raised a $6 million series A round in 2023. The company does not have a published drug pipeline on its website.

Chugai, for its part, has partnered with AI companies since late last decade, making it an early entrant into the biopharma-AI space. In 2018 Chugai linked up with the deep learning company Preferred Networks, paying the latter about $5 million (¥‎700 million) for access to its platform. More recently, Chugai partnered with SoftBank in January to use generative AI to accelerate drug development, with the aim of streamlining personnel and costs associated with clinical trials.





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Ascendion Wins Gold as the Artificial Intelligence Service Provider of the Year in 2025 Globee® Awards

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  • Awarded Gold for excellence in real-world AI implementation and measurable enterprise outcomes
  • Recognized for agentic AI innovation through ASCENDION AAVA platform, accelerating software delivery and unlocking business value at scale
  • Validated as a category leader in operationalizing AI across enterprise ecosystems—from generative and ethical AI to machine learning and NLP—delivering productivity, transparency, and transformation

BASKING RIDGE, N.J., July 7, 2025 /PRNewswire/ — Ascendion, a leader in AI-powered software engineering, has been awarded Gold as the Artificial Intelligence Service Provider of the Year in the 2025 Globee® Awards for Artificial Intelligence. This prestigious honor recognizes Ascendion’s bold leadership in delivering practical, enterprise-grade AI solutions that drive measurable business outcomes across industries.

The Globee® Awards for Artificial Intelligence celebrate breakthrough achievements across the full spectrum of AI technologies including machine learning, natural language processing, generative AI, and ethical AI. Winners are recognized for setting new standards in transforming industries, enhancing user experiences, and solving real-world problems with artificial intelligence (AI).

“This recognition validates more than our AI capabilities. It confirms the bold vision that drives Ascendion,” said Karthik Krishnamurthy, Chief Executive Officer, Ascendion. “We’ve been engineering the future with AI long before it became a buzzword. Today, our clients aren’t chasing trends; they’re building what’s next with us. This award proves that when you combine powerful AI platforms, cutting-edge technology, and the relentless pursuit of meaningful outcomes, transformation moves from promise to fact. That’s Engineering to the Power of AI in action.”

Ascendion earned this recognition by driving real-world impact with its ASCENDION AAVA platform and agentic AI capabilities, transforming enterprise software development and delivery. This strategic approach enables clients to modernize engineering workflows, reduce technical debt, increase transparency, and rapidly turn AI innovation into scalable, market-ready solutions. Across industries like banking and financial services, healthcare and life sciences, retail and consumer goods, high-tech, and more, Ascendion is committed to helping clients move beyond experimentation to build AI-first systems that deliver real results.

“The 2025 winners reflect the innovation and forward-thinking mindset needed to lead in AI today,” said San Madan, President of the Globee® Awards. “With organizations across the globe engaging in data-driven evaluations, this recognition truly reflects broad industry endorsement and validation.”

About Ascendion

Ascendion is a leading provider of AI-powered software engineering solutions that help businesses innovate faster, smarter, and with greater impact. We partner with over 400 Global 2000 clients across North America, APAC, and Europe to tackle complex challenges in applied AI, cloud, data, experience design, and workforce transformation. Powered by +11,000 experts, a bold culture, and our proprietary Engineering to the Power of AI (EngineeringAI) approach, we deliver outcomes that build trust, unlock value, and accelerate growth. Headquartered in New Jersey, with 40+ global offices, Ascendion combines scale, agility, and ingenuity to engineer what’s next. Learn more at https://ascendion.com.

Engineering to the Power of AI™, AAVA™, EngineeringAI, Engineering to Elevate Life™, DataAI, ExperienceAI, Platform EngineeringAI, Product EngineeringAI, and Quality EngineeringAI are trademarks or service marks of Ascendion®. AAVA™ is pending registration. Unauthorized use is strictly prohibited.

About the Globee® Awards
The Globee® Awards present recognition in ten programs and competitions, including the Globee® Awards for Achievement, Globee® Awards for Artificial Intelligence, Globee® Awards for Business, Globee® Awards for Excellence, Globee® Awards for Cybersecurity, Globee® Awards for Disruptors, Globee® Awards for Impact. Globee® Awards for Innovation (also known as Golden Bridge Awards®), Globee® Awards for Leadership, and the Globee® Awards for Technology. To learn more about the Globee Awards, please visit the website: https://globeeawards.com.

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Overcoming the Traps that Prevent Growth in Uncertain Times

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July 7, 2025

Today, with uncertainty a seemingly permanent condition, executives need to weave adaptability, resilience, and clarity into their operating plans. The best executives will implement strategies that don’t just sustain their businesses; they enable growth.





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