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Positioning & Distribution Will Determine the Winning Healthcare AI Startups, Investor Says 

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Healthcare AI startups continue to command strong investor interest while gaining more adoption across providers, payers and pharmaceutical companies. 

In the first half of this year, about 58% of all healthcare fundraising deals involved AI companies, marking a record pace. There were also at least 10 healthcare AI startups that reached valuations higher than $1 billion over the past year, as well as at least five multi-billion-dollar healthcare AI exits in 2025, according to recent data.

With a flood of AI companies vying for attention in healthcare, both investors and customers have to discern which tools deliver value versus those that are more hype than help.

Morgan Cheatham, partner and head of healthcare and life sciences at Breyer Capital, noted that the distinction between AI-first and AI-enabled reveals a company’s center of gravity, from which strategy naturally flows. 

“AI-first companies advance the science of computation, while AI-enabled companies excel at implementation and distribution. In practice, it is less a binary and more a spectrum, with most enduring companies blending elements of both,” he explained.

This framing alone does not determine a company’s longevity, though.

In Cheatham’s view, the companies that last will be those with strong positioning and distribution — the ones controlling key leverage points such as where AI compounds, data originates, workflows are streamlined, and networks come together. He thinks this will create value that incumbents struggle to provide.

He highlighted AI-powered oncology diagnostics startup Artera, which is one of Breyer’s portfolio companies. The startup operates at the point where data is first created and undergoes a key transformation — turning human tissue into structured, clinically usable insights, Cheatham said.

“Controlling this conversion point gives Artera architectural leverage. Once raw data has been converted into clinically actionable information, every downstream workflow, from diagnosis to treatment planning to reimbursement, is shaped by it.” he explained.

It’s still important to remember that with incumbents like Epic and others such as Doximity and R1 RCM entering the healthcare AI arena, it’s difficult for emerging startups to compete on breadth, Cheatham added.

To him, their edge lies in occupying the positions that incumbents are too slow to reach, as well as finding ways to distribute that incumbents can’t easily replicate. 

AI-driven clinical decision support platform OpenEvidence “demonstrates the power of nimble distribution” by delivering its product straight to clinicians free of charge, earning their trust at the point of care and bypassing the enterprise procurement process, Cheatham noted.

He also praised Iterative Health, an AI startup offering tools for gastrointestinal care, for showing how a smart business model can pair advanced computer vision with clinical trial recruitment in a way that benefits both medical practices and trial sponsors. He pointed to clinical evidence company Atropos Health too, which demonstrates how one platform can serve both providers and pharma companies by generating real-world clinical evidence that each can use.

“In crowded verticals, data and trust compound faster in aggregated platforms than in fragmented point solutions, which is why consolidation, not collapse, is the default outcome. This blend of technical edge and economic alignment is precisely where startups can differentiate,” Cheatham declared.

He added that AI creates abundance, not scarcity. 

When various companies chase the same vertical and operate on similar models, differentiation ends up eroding and markets tend to resolve to scale, Cheatham explained.

“Overhyped categories mark the places where market demand is clearest and entry points are most valuable. Even in a competitive landscape, this is prime real estate — the workflows everyone is fighting to own are the ones that matter most,” he remarked.

Margin pressure is always going to be more severe in healthcare, so buyers won’t really tolerate dozens of lookalike vendors. Instead, spending will concentrate on platforms that own key entry points and create value across different stakeholders, Cheatham stated.

Photo: We Are, Getty Images



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Fed governor Lisa Cook declared key property as ‘vacation home’, files show | US news

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A loan estimate for an Atlanta home purchased by Lisa Cook, the Federal Reserve governor accused of mortgage fraud by the Trump administration, shows that Cook had declared the property as a “vacation home”, according to a document reviewed by Reuters.

The document, dated 28 May 2021, was issued to Cook by her credit union in the weeks before she completed the purchase and shows that she had told the lender that the Atlanta property would not be her primary residence. The document appears to counter other documentation that Cook’s critics have cited in support of their claims that she committed mortgage fraud by reporting two different homes as her primary residence, two independent real-estate experts said.

Reuters was unable to reach Cook for comment. She has repeatedly denied any wrongdoing regarding her properties, which also include a home in Ann Arbor, Michigan, and an investment property in Massachusetts.

Administration officials led by Bill Pulte, director of the Federal Housing Finance Agency, have used mortgage documents from her Atlanta and Michigan properties to accuse Cook of claiming both as her “primary residence”. The allegedly false claims of residence, which could improve mortgage and tax implications for a homeowner, led Pulte to refer the matter to the Department of Justice, prompting a federal investigation and an order by Donald Trump to dismiss her.

Cook, who remains at the Federal Reserve, has sued the president to resist her dismissal. Reuters was unable to determine whether Pulte or administration officials are aware of Cook’s Atlanta loan estimate. Spokespeople at the FHFA, the agency led by Pulte, did not respond to a request for comment.

The documents cited by Pulte include standardized federal mortgage paperwork which stipulates that each loan obtained by Cook for the Atlanta and Michigan properties is meant for a “primary residence”. But documentation reviewed by Reuters for the Atlanta home, filed with a court in Georgia’s Fulton county, clearly says the stipulation exists “unless Lender otherwise agrees in writing”. The loan estimate, a document prepared by the credit union, states “Property Use: Vacation Home”.

The document appears to help Cook’s case, said two real-estate experts who aren’t involved in representing her. That’s because it indicates that during the loan-application process, she told the lender she intended to use the property as a vacation home.

The lender, Washington-based Bank-Fund Staff Federal Credit Union, did not respond to a request for comment.

In another point that could help Cook’s case, she never requested a tax exemption for the Georgia home as a primary residence, according to property records and a Fulton county tax official.

A separate document reviewed by Reuters, related to a federal form completed by Cook as she obtained security clearance for her role at the Federal Reserve, shows that in December 2021 she also declared the Atlanta property as a “second home.” Though unrelated to the mortgage, the declaration on that document, a supplement to a US government national security form known as SF-86, is consistent with the claim on her Atlanta loan summary.

Surrounding the accusations against Cook is a battle over Trump’s effort to wield more control over the Federal Reserve, the central bank of the United States and an independent institution meant to be free of political meddling. Trump has often criticized Fed governors because of their reluctance to cut interest rates since he returned to the White House earlier this year.

Amid the controversy, the personal finances of other government officials and their families have also come into question by rival politicians, the media and others.

Last week, Reuters reported that Pulte’s own father and stepmother had declared two homes in two different states as their primary residence, prompting a town in Michigan to remove a tax exemption for their home there and charge the couple for back taxes. Pulte and his parents didn’t respond to requests for comment about the matter.



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As US edges closer to stagflation, economists blame Trump policies | US economy

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It’s a strange time for the US economy. Prices are rising, jobs growth has stalled, uncertainty is everywhere and stock markets have soared to record highs. Against this background a scary word last used in the 1970s is being uttered again: stagflation.

GDP chart

Stagflation is the term that describes “stagnant” growth combined with “inflation” of prices. It means that companies are producing and hiring less, but prices are still going up. It’s a scenario that some economists say can be worse than a recession.

The last time the US saw a period of prolonged stagflation was in the 1970s during the oil shock crisis. Higher oil prices caused inflation to rise, while unemployment rose as consumers cut back on spending.

For now, the US economy isn’t experiencing stagflation, but recent data has shown it is edging closer to it.

After Donald Trump’s tariffs were announced in the spring, official data initially suggested the economy was shaking them off. New jobs were being added to the economy at a stable pace, while inflation went down to 2.3% – the lowest it had been since 2021.

However, when new labor market data was released in August, it became clear that there had been an impact on hiring that had been slow to appear in the data. Initial job figures for May and June were revised down by 258,000. While figures in July and August were slightly stronger, it was still a marked drop compared with earlier in the year.

Meanwhile, inflation started crawling back up in April. In August, the annualized inflation rate hit 2.9%, the highest since January.

Inflation chart

Brett House, an economist at Columbia Business School, said that surveys of economists showed expectations of a recession for the year ahead was at a three-year low in January. Growth was expected to remain solid, and inflation was expected to continue easing.

“Both of those expectations have been turned around by the set of policies and their erratic implementation,” House said. “We’ve seen growth forecasts for the remainder of this year cut substantially, and we have seen inflation forecasts pushed up.”

In other words, the economy has both become more stagnant and inflationary – stagflation.

Economists are pointing to two policies coming out of the White House that are pushing the economy closer toward stagflation.

Trump’s crackdown on immigration has cut down the number of available workers and also increased the cost of hiring. And when it comes to prices, tariffs have just started to have a noticeable impact as companies pass tariff costs on to consumers.

Investors are banking on hopes the Federal Reserve cutting interest rates next week, but the future of the US economy remains uncertain.

In his closely watched speech at the Fed’s Jackson Hole symposium last month, the Fed chair, Jerome Powell, outlined the “shifting balance of risks” that have appeared over the summer.

“While the labor market appears to be in balance, it is a curious kind of balance that results from a marked slowing in both the supply of and demand for workers,” Powell said. Meanwhile, “higher tariffs have begun to push up prices in some categories of goods.”

Stagflation weakens the Fed’s ability to balance the economy. Adjusting interest rates can help balance out unemployment and inflation, but only if one is rising. When inflation surged to 9.1% in summer 2022, raising interest rates helped bring prices down. Inflation went down to below 2.5%, but the unemployment rate went up in the meanwhile, from a low of 3.4% in 2023 to 4.3% this past August.

The Fed actually has more power during a recession, which economists broadly define as a period of slowed economic activity. When Covid lockdowns caused a recession, with massive unemployment, in 2020, the Fed lowered interest rates down to near zero to stimulate the economy.

Because we’re not seeing stagflation yet, the Fed moving rates down next week could help the labor market without causing prices to soar. But the move comes with uncertainty.

“Say stagflation is happening, but at a very slow pace, because firms are waiting to pass through [the cost of tariffs],” said Sebnem Kalemli-Ozcan, an economist at Brown University. “Firms are going to start seeing demand increase and say: ‘Oh, now I can pass through my higher costs on to more consumers.’ … Then we are going to see inflation.”

One analysis from Goldman Sachs said that US consumers had already absorbed 22% of the cost of tariffs, and that they could eventually take on 67% if current tariffs continue.

If prices continue to rise, and the labor market continues to slow, stagflation will get stronger.

jobs chart

“If [stagflation] happens, it’s a very depressive situation because people are going to lose their jobs, unemployment is going to increase and people who are looking for jobs are going to have a very hard time finding jobs. That’s going to be the hard part,” Kalemli-Ozcan said.

The Yale Budget Lab estimated that Trump’s tariffs could increase the number of Americans living in poverty by at least 650,000 as tariffs become what the lab calls an “indirect tax”.

The Trump administration has urged Americans to be patient with the impacts of the tariffs and has claimed that recent economic data has been “rigged” against the president.

“The real numbers that I’m talking about are going to be whatever it is, but will be in a year from now,” Trump said earlier this month. “You’re going to see job numbers like our country has never seen.”



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CEO of company behind Harwood AI data center answers commonly asked questions – InForum

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HARWOOD, N.D. — As a Texas company prepares to break ground this month on a

$3 billion artificial intelligence data center

north of Fargo, readers have asked several questions about the facility.

The Forum spoke this week with Applied Digital Chairman and CEO Wes Cummins about the 280-megawatt facility planned for east of Interstate 29 between Harwood and Fargo. The 160-acre center will sit on 925 acres near the Fargo Park District’s North Softball Complex.

The Harwood City Council voted unanimously on Wednesday, Sept. 10, to rezone the land for the center from agricultural to light industrial. With the vote also came final approval of the building permit for the center, meaning Applied Digital can break ground on the facility this month.

“We’re grateful for the City of Harwood’s support and look forward to continuing a strong partnership with the community as this project moves ahead,” Cummins said after the vote.

Applied Digital CEO and Chairman Wes Cummins talks about his company and its plans for Harwood during a meeting on Tuesday, Sept. 2, 2025, at the Harwood Community Center.

Alyssa Goelzer / The Forum

Applied Digital plans to start construction this month and open partially by the end of 2026. The facility should be fully operational by early 2027, the company said.

The project should create 700 construction jobs while the facility is built, Applied Digital said. The center will need more than 200 full-time employees to operate, the company said. The facility is expected to generate tax revenue and economic growth for the area, but those estimates have not been disclosed.

The facility has generated

questions and protest.

Here are some questions readers had about the facility.

What will the AI data center be used for?

Applied Digital said it develops facilities that provide “high-performance data centers and colocations solutions for artificial intelligence, cloud, networking, and blockchain industries.” AI is used to run applications that make computers functional, Cummins said.

“ChatGPT runs in a facility like this,” he said. “There’s just enormous amounts of servers that can run GPUs (graphic processing units) inside of the facility and can either be doing training, which is making the product, or inference, which is what happens when people use the product.”

081825.N.FF.HarwoodDataCenter

Applied Digital’s $3 billion data center will be constructed just southeast of the town of Harwood, North Dakota.

Map by The Forum

Applied Digital hasn’t announced what tenants would use Polaris Forge 2, the name for the Harwood facility. At a Harwood City Council meeting, Cummins said the company markets to companies in the U.S. like Google, Meta, Amazon and Microsoft.

“The demand for AI capacity continues to accelerate, and North Dakota continues to be one of the most strategic locations in the country to meet that need,” he said. “We have strong interest from multiple parties and are in advanced negotiations with a U.S. based investment-grade hyperscaler for this campus, making it both timely and prudent to proceed with groundbreaking and site development.”

AI data centers need significant amounts of electricity to operate, Cummins said. Other centers have traditionally been built near heavily populated areas, but that isn’t necessary, he said.

North Dakota produces enough energy to export it out of state, Cummins said. The Fargo area also has the electrical grid in place to connect to that energy, he said.

“A lot of North Dakotans, especially the leaders of North Dakota, want to better utilize the energy produced by North Dakota for economic benefit inside of the state versus exporting it to neighboring states or to Canada,” he said.

North Dakota’s cold climate much of the year also will keep the center cooler than in states like Texas, meaning the facility will use significantly less power than in warmer states, Cummins said.

“We get much more efficiency out of the facility,” he said. “Those aspects make North Dakota, in my opinion, an ideal place for this type of AI infrastructure.”

A foreground of a leafy crop stretches toward the horizon, where metal grain elevators and metal storage buildings stand against a gray sky.

The Harwood elevator on Thursday, Aug. 28, 2025, looms behind the land designated for the construction of Applied Digital’s 280-megawatt data center.

David Samson / The Forum

How much water will the center use?

Cummins acknowledged other AI data centers around the world use millions of gallons of water a day. Applied Digital designed a closed-loop system so the North Dakota centers use as little water as possible, Cummins said.

He compared the cooling system to a car radiator. The centers will use glycol liquid to run through the facilities and servers, Cummins said. After cooling the equipment, the liquid goes through chillers, much like a heat pump outside of a house. Once cooled, the liquid will recirculate on a continuous loop, he said.

People who operate the facility will use water for bathroom breaks and drinking, much like a person in a house or a car, he said.

“The data center, even with the immense size, we expect it to use the same amount of water as roughly a single household,” he said. “The reason is the people inside.”

090425.N.FF.HarwoodAI

Duncan Alexander and dog Valka protest a proposed AI data center before a Planning and Zoning meeting on Tuesday, Sept. 2, 2025, in Harwood, N.D.

Alyssa Goelzer / The Forum

Will the AI center increase electricity rates?

Applied Digital claims that electricity rates will not go up for local residents because of the data center.

“Data centers pay a large share of fixed utility costs, which helps spread expenses across more users,” the company said.

Applied Digital’s center in Ellendale, North Dakota, much like the one to be built in Harwood, uses power produced in the state, Cummins said. The Ellendale center, which runs on about 200 megawatts a year, saved ratepayers $5.3 million in 2023 and $5.7 million last year, he said.

“Utilizing the infrastructure more efficiently can actually drive rates down,” Cummins said, adding he expects rate savings for Harwood as well.

How much noise will the center make?

Applied Digital’s concrete walls should content the noise from computers, Cummins said. What residents will hear is fan noise from heat pumps used to cool the facility, he said.

“It will sound like the one that runs outside of your house,” he said in describing that the facility will create minimal noise.

The loudest noise will be construction of the facility, Cummins said.

The facility only will cover 160 acres, but Applied Digital is buying 925 acres of land, with the rest of the space serving as a sound buffer, he said. People who live nearby may hear some sound, he acknowledged.

“If you’re a half mile or more from the facility, you will very unlikely hear anything,” he said.

About 300 people showed up to a town hall meeting on Monday, Aug. 25, 2025, at the Harwood Community Center to listen and to discuss a new AI data center that is planned to be built in Harwood.

About 300 people showed up to a town hall meeting on Monday, Aug. 25, 2025, at the Harwood Community Center to listen and to discuss a new AI data center that is planned to be built in Harwood, N.D.

Chris Flynn / The Forum

Has Applied Digital conducted an environmental study?

The facility won’t create emissions or other hazards that would require an environmental impact study, Cummins said.

Why move so fast to approve the facility?

Some have criticized Applied Digital and the Harwood City Council for pushing the approval process so quickly. Applied Digital announced the project in mid-August, and the city approved it in less than a month.

Cummins acknowledged that concern but noted the industry is moving fast. The U.S. is competing with China to create artificial intelligence, an industry that is not going away, Cummins said.

“I do believe we are in a race in the world for super intelligence,” he said. “It’s a race amongst companies in the U.S., but it’s also a race against other countries. … I do think it’s very important the U.S. win this AI race to super intelligence and then to artificial general intelligence.”

Applied Digital said it wanted to finish foundation and grading work on the project before winter sets in, meaning it needed an expedited approval timeline.

People in Harwood have shown overwhelming support, Cummins said, adding that protesters mostly came from other cities.

“I can’t think of a project that would spend this amount of money and have this kind of economic benefit for a community and a county and a state and have this low of a negative impact,” he said. “I think these types of projects are fantastic for these types of communities.”





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