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Eight healthy babies born after IVF using DNA from three people | Science

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Doctors in the UK have announced the birth of eight healthy babies after performing a groundbreaking procedure that creates IVF embryos with DNA from three people to prevent the children from inheriting incurable genetic disorders.

The mothers were all high risk for passing on life-threatening diseases to their babies due to mutations in their mitochondria, the tiny structures that sit inside cells and provide the power they need to function.

News of the births and the children’s health has been long-anticipated by doctors around the world after the UK changed the law to allow the procedure in 2015. The fertility regulator granted the first licence in 2017 to a fertility clinic at Newcastle University where doctors pioneered the technique.

The four boys and four girls, including one set of identical twins, were born to seven women and have no signs of the mitochondrial diseases they were at risk of inheriting. One further pregnancy is ongoing.

Prof Doug Turnbull, who was part of the team that spent more than two decades developing the procedure, said the healthy births were reassuring for researchers and the families affected. “You are inevitably thinking it’s great for the patients and that is a relief,” he said.

Prof Mary Herbert, another senior member of the team, said to have eight healthy babies from the procedure was “rewarding for all of us”.

The vast majority of a human’s 20,000 genes are curled up in the nucleus of nearly every cell in the body. But the fluid surrounding the nucleus contains hundreds to thousands of mitochondria that carry their own set of 37 genes. Mutations in these genes can impair or completely disable mitochondria with catastrophic effects.

People inherit all their mitochondria from their biological mother. Mutations in the tiny battery-like structures can affect all the children a woman has.

The first symptoms of mitochondrial disease tend to appear in early childhood as energy-hungry organs such as the brain, heart and muscles start to fail. Many affected children have developmental delays, require wheelchairs and die young. About one in 5,000 newborns are affected.

Mitochondrial donation treatment, or MDT, aims to prevent children from inheriting mutated mitochondria. The procedure involves fertilising the mother’s egg with the father’s sperm and then transferring the genetic material from the nucleus into a fertilised healthy donor egg that has had its own nucleus removed. This creates a fertilised egg with a full set of chromosomes from the parents, but healthy mitochondria from the donor. The egg is then implanted into the womb to establish a pregnancy.

How mitochondrial donation therapy works

The first eight babies born to the procedure are described in two papers in the New England Journal of Medicine. All eight were healthy at birth. One child developed a urinary infection that was treated, and another developed muscle jerks that resolved on their own. A third child developed high blood fat and a disturbance in their heart rhythm, which was also treated. The condition is thought to be related to a medical issue the mother had in pregnancy.

Genetic tests showed that the babies had no or low levels of mutant mitochondria, with some carried over from the mother during the procedure. While the levels are considered too low to cause disease, it suggests the procedure could still be improved.

“All the children are well and they’re continuing to meet their developmental milestones,” said Bobby McFarland, director of the NHS Highly Specialised Service for Rare Mitochondrial Disorders at Newcastle hospitals NHS foundation trust. Five of the children are less than a year old, two are aged between one and two, and the other child is older.

The mother of one of the girls said: “As parents, all we ever wanted was to give our child a healthy start in life. After years of uncertainty this treatment gave us hope – and then it gave us our baby … we’re overwhelmed with gratitude. Science gave us a chance.”

Some women who carry the genetic disorders produce eggs with varying levels of faulty mitochondria. For them, a technique called pre-implantation genetic testing (PGT) can be used to select eggs for IVF that have a very low chance of passing on a disease. Other women do not have this choice because all their eggs have high levels of mutations.

The Newcastle team said eight of 22 (36%) of women became pregnant after MDT and 16 of 39 (41%) of women became pregnant after PGT. It is unclear why the rates differed, but some mitochondrial mutations may have knock-on effects on fertility.

Writing in an accompanying editorial, Robin Lovell-Badge, a principal group leader at the Francis Crick Institute in London, said the long road to this point had “no doubt been frustrating to women at risk of having children with mtDNA disease”, but praised the scientists’ cautious approach.



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Craig Jones puts Chael Sonnen to sleep twice in CJI 2 superfight

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Chael Sonnen stepped in as a late replacement for Gable Steveson at Sunday night’s Craig Jones Invitational 2 in Las Vegas and did his best to survive against Craig Jones.

In a match scheduled for three five-minute rounds, Sonnen managed to get tapped twice with the same move.

A former UFC middleweight and light heavyweight title challenger, Sonnen immediately took Jones to the ground to find himself locked in a buggy choke. The choke was tight, and Sonnen apparently went to sleep.

Sonnen regained his senses, and both athletes agreed to go at it again. Sonnen took Jones down again, going for a leg lock with no real danger to a grappler of Jones’ caliber. The CJI founder against attacked with the buggy choke, again having Sonnen go lights out.

McCarthy couldn’t help but laugh as Sonnen tried to make it best three out of five — and the crowd chanted to get the two go at it again —, but the referee called the end of the contest.

The official result was read as Jones being victorious via double buggy choke.

Watch the second finish below.



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Liverpool agrees to British-record deal for Alexander Isak, sources say

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Liverpool have agreed to a British-record deal to sign striker Alexander Isak from Newcastle United, sources told ESPN.

The Premier League champions have had a £125M bid accepted to sign the Sweden international, who is expected to undergo a medical ahead of Monday’s transfer deadline.

It brings an end to one of the summer’s most-protracted transfer sagas, with Isak having spent more than a month agitating for a move away from Newcastle. The 25-year-old did not join the club on their preseason tour of the Far East and has not featured for Eddie Howe’s side this season.

He also released a sensational statement earlier this month in which he claimed promises had been “broken” by the Newcastle hierarchy and insisted a move this summer would be in the best interests of all parties.

Isak is now set to become the most expensive signing in Premier League history, surpassing Chelsea’s Moisés Caicedo who joined the London club for £115M from Brighton & Hove Albion in the summer of 2023. It marks the second time this summer that Liverpool have broken their transfer record, with Arne Slot’s side having committed spending an initial £100M (plus a potential £16M in add-ons) to sign Florian Wirtz from Bayer Leverkusen in June.



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Donald Trump as the wildcard and other takeaways for India-China relationship

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Vikas PandeyIndia editor and

Stephen McdonellChina correspondent

Reuters Narendra Modi and Xi Jinping smile for the cameras on stage against a shimmering blue and orange backdrop. Modi is wearing a blue vest over a white kurta with a golden pocket handkerchief, Xi is wearing a navy blue suit and a maroon tie.Reuters

Modi and Xi posed for pictures in Tianjin on Monday

The view from India

Just a few months ago, the armed forces of India and Pakistan were locked in a brief but deadly conflict.

The conflict indirectly involved a third nation – China. Pakistan’s armed forces heavily used China-made equipment, including fighter jets and radar systems.

A senior army officer in Delhi said Beijing also provided “live inputs” to Pakistan on Indian positions.

India didn’t take a public stand against China, but this left many asking if Delhi should continue on the path of normalising relations with Beijing.

Less than six months later, peace talks between the two Asian giants have been turbocharged by decisions taken thousands of miles away in Washington DC.

The Trump administration has imposed 50% tariffs on Indian imports, saying Delhi was being punished for its refusal to stop buying oil from Russia.

Delhi had two clear choices after this stunning onslaught from a trusted ally.

The first was to cave in and stop buying Russian oil. But it has refused to do so, largely because Russia is an “all-weather” ally and giving into pressure doesn’t suit Indian Prime Minister Narendra Modi’s strongman image.

The second was to stand firm and seek other opportunities and India appears to have to chosen this option for now.

It’s also pragmatic to look no further when your neighbour is the world’s second-largest economy and a global manufacturing powerhouse.

It was in this context, that Modi met Chinese President Xi Jinping in Tianjin over the weekend.

Statements from the two sides were not heavy on details, though they promised to work through their differences to benefit their collective population of 2.8 billion people.

The immediate takeaway from the meeting was the resumption of direct flights between the two countries and making the process of issuing visas simpler.

But beyond the promise of “the elephant and the dragon” coming together, the two countries still have major roadblocks to clear before they are able to engage meaningfully.

Their first challenge comes from their immediate history.

Modi has invested personally in the India-China relationship since coming to power in 2014, visiting the neighbouring country five times until 2018.

But the 2020 border clash put brakes on this momentum and it has taken seven long years for Modi to visit China again.

The key to making further progress will depend on how the two countries deal with their border issues.

Tens of thousands of troops from both countries are still deployed at their contested borders – though there are ongoing talks between their civilian and military leaders to ease the situation.

AFP via Getty Images A man wearing an orange turban and white top holds up two pictures of Donald Trump and shouts angrily at the camera. Behind him are a crowd of men holding up signs stating "roll back the tariffs imposed on India".AFP via Getty Images

The US-imposed 50% tariffs on India has caused some anger

Both Chinese and Indian readouts after the meeting this weekend talked about maintaining peace at the border and “not turning their differences into disputes”.

For India, there is the issue of a burgeoning trade deficit with China, amounting to more than $99bn (£73bn).

Both countries still have high tariffs and duties against each other in many sectors.

Beijing would want India to open its market of 1.4 billion people to Chinese products, but Delhi would be wary of doing that without addressing the deficit.

The outreach to China, which started with Modi meeting Xi in Kazan last year, may have been supercharged by Trump tariffs, but ground realities for India remain unchanged.

The Modi-Xi meeting is being seen as part of India’s policy of “strategic autonomy” but it will also cause more geopolitical challenges for Delhi.

India is due to host the Quad (which includes Japan, Australia and the US) summit later this year. The forum was largely seen as a challenge to China’s dominance in the Indo-Pacific region.

It’s not clear if Trump will attend, but if he does and says something against China, it will immediately test the renewed synergy between Delhi and Beijing.

Delhi is also part of several other multilateral forums that are perceived as anti-China and anti-Russia.

How Delhi plays its strategic autonomy in the next few months will very much influence the direction India-China ties take.

For now, it’s clear that India-US ties are at an all-time low. A Trump aide recently called the Russia-Ukraine conflict “Modi’s war”.

Delhi has also consistently denied that Trump played any role in the ceasefire between India and Pakistan in May – this has become a constant irritant for the US president.

Despite this, India has refrained from imposing retaliatory tariffs against the US and has left the door ajar for further negotiations. After all, the US is India’s biggest trading partner.

Will going closer to China help India’s negotiations with the US or will it have the opposite impact?

This is the question that will likely dominate geopolitical discussions in Delhi and beyond in the coming months.

Hindustan Times via Getty Images File picture from 2020 showing men in New Delhi wearing white kurtas, jeans and shirts burning print-outs of Xi Jinping's portrait and the Chinese flagHindustan Times via Getty Images

Tensions ran high following the Galwan Valley incident in 2020 – but they have since cooled down somewhat

The view from China

When Xi Jinping met Narendra Modi he used what has become his favourite catchphrase for China-India relations: “The dragon and the elephant should come together”.

During “this period of transformation,” he added that it was vital for the world’s most populous nations to be friends and good neighbours.

In a case of spectacular timing, Prime Minister Modi’s visit has coincided with Donald Trump’s tariffs of up to 50% on India exports to the US.

This represents quite a hit on the country’s economy so New Delhi would be looking around for other business partners.

Look no further than right here, Xi may well say, as his administration attempts to rebuild from the wreckage of China-India relations following years of tension between the two.

And, if their official readouts are anything to go by, Modi’s attendance at the Tianjin Summit of the Shanghai Cooperation Organisation seems to have paid off.

His published comments to Xi were much more specific than the those coming the other way.

There is now a very good window for Beijing and New Delhi to repair their strained relationship.

China’s leader knows that Donald Trump’s tariff onslaught is pushing India away from the United States and that this great economic rival needs other partnerships.

Considerable obstacles remain.

They include China’s backing of India’s key rival Pakistan; interaction of all types has been in the doldrums; angry rhetoric from both governments (over many years) has created a climate of suspicion between the Asian heavyweights and their high-mountain border dispute has stirred nationalist sentiment on both sides of the frontier.

However, with the latter of these, this meeting would appear to confirm that pressure has already eased.

Last Thursday China’s Defence Ministry spokesman was talking up the success of discussions between the representatives of China and India aimed at stopping the clashes along their disputed border.

He spoke of “win-win cooperation” and celebrating the 75th anniversary of ties between the two nations.

Xi also knows that the symbolism of having Modi in China right now is considerable, that images of them shaking hands and standing side-by-by side – as the Trump tariffs on India kick in – can be a powerful propaganda tool which is made even more significant by the fact that this is a multilateral gathering.

The two will not only be joined by Vladimir Putin but by the other SCO governments like Turkey (a member of Nato), Saudi Arabia (a key US ally), Iran (a key enemy of the US) as well as Qatar, Egypt and Pakistan.

And all of this in the days before Beijing holds a massive display of military might with a parade through the heart of the capital.



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