Jobs & Careers
DeepMind Launches AlphaGenome to Predict How DNA Variants Affect Gene Regulation
DeepMind has launched AlphaGenome, a new artificial intelligence (AI) model that can predict how single DNA variants affect gene regulation across the human genome. The model, now available via API for non-commercial research, marks an advance in understanding the genome’s non-coding regions, that is, areas long considered the “dark matter” of DNA.
AlphaGenome can analyse up to 1 million DNA base pairs and delivers high-resolution predictions about thousands of molecular processes, such as where genes begin and end, how RNA is spliced and which proteins bind to DNA. This predictive ability, according to DeepMind, offers a “unifying model” to help scientists better understand gene function and the impact of mutations.
“It’s a milestone for the field,” Dr Caleb Lareau of Memorial Sloan Kettering Cancer Centre said in the blog post. “For the first time, we have a single model that unifies long-range context, base-level precision and state-of-the-art performance across a whole spectrum of genomic tasks.”
Unlike earlier models such as Enformer and AlphaMissense, which focus primarily on protein-coding regions, AlphaGenome is designed to analyse the remaining 98% of the genome, non-coding regions that regulate gene activity and are often linked to disease. DeepMind claims the model offers a new way to explore these vast areas with unprecedented detail.
The architecture combines convolutional layers to detect short patterns, transformer models to capture long-range dependencies and final layers to produce predictions. According to the company, AlphaGenome outperformed top external models in 22 of 24 sequence prediction benchmarks and matched or exceeded others in 24 of 26 variant-effect tasks.
In a test case involving T-cell acute lymphoblastic leukaemia (T-ALL), AlphaGenome successfully predicted how specific mutations activate the cancer-related TAL1 gene by creating a new binding site for the MYB protein, replicating a known disease mechanism. The result underscored the model’s potential to link non-coding variants to disease outcomes.
“AlphaGenome will be a powerful tool for the field,” Professor Marc Mansour of University College London explained in the post. “Determining the relevance of different non-coding variants can be extremely challenging, particularly to do at scale. This tool provides a crucial piece of the puzzle.”
DeepMind acknowledges some limitations. It still struggles with predicting the effects of very distant DNA interactions, over 1 lakh letters apart, and has not been validated for personal genome interpretation or clinical use.
Researchers are invited to access AlphaGenome through its preview API and collaborate via DeepMind’s community forum. The company says the model could accelerate discovery across disease research, synthetic biology, and basic science.
“We hope AlphaGenome will deepen our understanding of the complex cellular processes encoded in the DNA sequence and drive exciting new discoveries in genomics and healthcare,” DeepMind said in a statement.
Jobs & Careers
HCLSoftware Launches Domino 14.5 With Focus on Data Privacy and Sovereign AI
HCLSoftware, a global enterprise software leader, launched HCL Domino 14.5 on July 7 as a major upgrade, specifically targeting governments and organisations operating in regulated sectors that are concerned about data privacy and digital independence.
A key feature of the new release is Domino IQ, a sovereign AI extension built into the Domino platform. This new tool gives organisations full control over their AI models and data, helping them comply with regulations such as the European AI Act.
It also removes dependence on foreign cloud services, making it easier for public sector bodies and banks to protect sensitive information.
“The importance of data sovereignty and avoiding unnecessary foreign government influence extends beyond SaaS solutions and AI. Specifically for collaboration – the sensitive data within email, chat, video recordings and documents. With the launch of Domino+ 14.5, HCLSoftware is helping over 200+ government agencies safeguard their sensitive data,” said Richard Jefts, executive vice president and general manager at HCLSoftware
The updated Domino+ collaboration suite now includes enhanced features for secure messaging, meetings, and file sharing. These tools are ready to deploy and meet the needs of organisations that handle highly confidential data.
The platform is supported by IONOS, a leading European cloud provider. Achim Weiss, CEO of IONOS, added, “Today, more than ever, true digital sovereignty is the key to Europe’s digital future. That’s why at IONOS we are proud to provide the sovereign cloud infrastructure for HCL’s sovereign collaboration solutions.”
Other key updates in Domino 14.5 include achieving BSI certification for information security, the integration of security event and incident management (SEIM) tools to enhance threat detection and response, and full compliance with the European Accessibility Act, ensuring that all web-based user experiences are inclusive and accessible to everyone.
With the launch of Domino 14.5, HCLSoftware is aiming to be a trusted technology partner for public sector and highly regulated organisations seeking control, security, and compliance in their digital operations.
Jobs & Careers
Mitsubishi Electric Invests in AI-Assisted PLM Systems Startup ‘Things’
Mitsubishi Electric Corporation announced on July 7 that its ME Innovation Fund has invested in Things, a Japan-based startup that develops and provides AI-assisted product lifecycle management (PLM) systems for the manufacturing industry.
This startup specialises in comprehensive document management, covering everything from product planning and development to disposal. According to the company, this marks the 12th investment made by Mitsubishi’s fund to date.
Through this investment, Mitsubishi Electric aims to combine its extensive manufacturing and control expertise with Things’ generative AI technology. The goal is to accelerate the development of digital transformation (DX) solutions that tackle various challenges facing the manufacturing industry.
In recent years, Japan’s manufacturing sector has encountered several challenges, including labour shortages and the ageing of skilled technicians, which hinder the transfer of expertise. In response, DX initiatives, such as the implementation of PLM and other digital systems, have progressed rapidly. However, these initiatives have faced challenges related to development time, cost, usability, and scalability.
Komi Matsubara, an executive officer at Mitsubishi Electric Corporation, stated, “Through our collaboration with Things, we expect to generate new value by integrating our manufacturing expertise with Things’ generative AI technology. We aim to leverage this initiative to enhance the overall competitiveness of the Mitsubishi Electric group.”
Things launched its ‘PRISM’ PLM system in May 2023, utilising generative AI to improve the structure and usage of information in manufacturing. PRISM offers significant cost and scalability advantages, enhancing user interfaces and experiences while effectively implementing proofs of concept across a wide range of companies.
Atsuya Suzuki, CEO of Things, said, “We are pleased to establish a partnership with Mitsubishi Electric through the ME Innovation Fund. By combining our technology with Mitsubishi Electric’s expertise in manufacturing and control, we aim to accelerate the global implementation of pioneering DX solutions for manufacturing.”
Jobs & Careers
AI to Track Facial Expressions to Detect PTSD Symptoms in Children
A research team from the University of South Florida (USF) has developed an AI system that can identify post-traumatic stress disorder (PTSD) in children.
The project addresses a longstanding clinical dilemma: diagnosing PTSD in children who may not have the emotional vocabulary, cognitive development or comfort to articulate their distress. Traditional methods such as subjective interviews and self-reported questionnaires often fall short. This is where AI steps in.
“Even when they weren’t saying much, you could see what they were going through on their faces,” Alison Salloum, professor at the USF School of Social Work, reportedly said. Her observations during trauma interviews laid the foundation for collaboration with Shaun Canavan, an expert in facial analysis at USF’s Bellini College of Artificial Intelligence, Cybersecurity, and Computing.
The study introduces a privacy-first, context-aware classification model that analyses subtle facial muscle movements. However, instead of using raw footage, the system extracts non-identifiable metrics such as eye gaze, mouth curvature, and head position, ensuring ethical boundaries are respected when working with vulnerable populations.
“We don’t use raw video. We completely get rid of subject identification and only keep data about facial movement,” Canavan reportedly emphasised. The AI also accounts for conversational context, whether a child is speaking to a parent or a therapist, which significantly influences emotional expressivity.
Across 18 therapy sessions, with over 100 minutes of footage per child and approximately 185,000 frames each, the AI identified consistent facial expression patterns in children diagnosed with PTSD. Notably, children were more expressive with clinicians than with parents; a finding that aligns with psychological literature suggesting shame or emotional avoidance often inhibits open communication at home.
While still in its early stages, the tool is not being pitched as a replacement for therapists. Instead, it’s designed as a clinical augmentation, a second set of ‘digital’ eyes that can pick up on emotional signals even trained professionals might miss in real time.
“Data like this is incredibly rare for AI systems,” Canavan added. “That’s what makes this so promising. We now have an ethically sound, objective way to support mental health assessments.”
If validated on a larger scale, the system could transform mental health diagnostics for children—especially for pre-verbal or very young patients—by turning non-verbal cues into actionable insights.
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