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AI detects hidden movement clues linked to Parkinson’s disease

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Scientists have developed an artificial intelligence system capable of identifying subtle signs of brain disorders, including Parkinson’s disease, by analyzing simple video recordings of a person’s hand movements. The technology successfully pinpointed minute motor impairments in individuals whose performance had been judged as perfectly normal by expert neurologists, opening a new avenue for detecting neurodegenerative conditions at their earliest stages. The findings are published in Nature.

Researchers are persistently searching for better ways to identify neurodegenerative diseases like Parkinson’s disease before obvious symptoms appear. Early detection can be essential for managing the condition and developing treatments that might slow its progression. A major challenge is that the initial changes in motor function are often too slight for a doctor to see during a standard clinical examination. This makes it difficult to diagnose the disease or to identify individuals who are at high risk.

One such high-risk group includes people with a condition known as idiopathic REM Sleep Behavior Disorder. This is a sleep disorder where individuals physically act out their dreams, sometimes with vigorous movements. A large majority of people diagnosed with this sleep disorder will eventually develop Parkinson’s disease or a related condition. This makes them an ideal population for studying the earliest, or prodromal, signs of neurodegeneration.

The core motor symptom of Parkinson’s disease is known as bradykinesia, which is a general term for slowness of movement. This can be accompanied by other related issues, such as hypokinesia, which refers to movements that are too small in amplitude. Another key indicator is the “sequence effect,” where repetitive movements become progressively slower or smaller over time.

While these features are hallmarks of established Parkinson’s disease, it has been unclear if they are present in a detectable way in very early stages or in at-risk individuals with REM Sleep Behavior Disorder. Current methods for quantifying these subtle changes often require specialized, expensive equipment like accelerometers or optical trackers, limiting their widespread use.

To overcome these barriers, a team of researchers from the University of Florida sought to determine if an automated analysis of standard video recordings could unmask these hidden motor deficits. They hypothesized that their video-based approach could detect movement problems in people with early Parkinson’s disease even when a clinician could not, and that some of these features, especially the sequence effect, would also be present in individuals with the sleep disorder.

To test their ideas, the researchers recruited a total of 66 participants, who were divided into three groups. The first group consisted of 18 patients who had been diagnosed with early-stage Parkinson’s disease. The second group was made up of 16 individuals who had a confirmed diagnosis of idiopathic REM Sleep Behavior Disorder. The final group included 32 healthy adults with no history of neurological or sleep disorders to serve as a control group.

All participants underwent a standard neurological motor examination, which was recorded on video using a consumer-grade camera. A central part of this exam is the Finger Tapping task, where a person is asked to repeatedly tap their index finger against their thumb as quickly and as widely as possible for about ten seconds.

A fellowship-trained movement disorders neurologist evaluated and scored each participant’s performance on the Finger Tapping task using a standard clinical scale from 0 to 4, where a score of 0 signifies normal movement and a score of 4 indicates severe impairment. For their analysis, the researchers selected only the videos of finger-tapping performances that received a perfect score of 0. This selection ensured that any motor impairments the artificial intelligence might find would be truly subclinical, meaning they were invisible to the trained human eye.

The selected videos were then processed using a specialized software tool that employs a deep learning model. This model automatically identified and tracked the positions of 21 distinct points on the hand in every frame of the video. From this tracking data, the system calculated the distance between the tip of the index finger and the tip of the thumb throughout the task. This measurement created a continuous signal that represented the opening and closing of the fingers over time.

The researchers then extracted four key kinematic features from this signal for each participant: average movement amplitude (how wide the fingers opened), average movement speed, the decrement in amplitude (how much the movement size decreased from the beginning to the end of the task), and the decrement in speed (how much the movement speed declined).

The artificial intelligence system revealed clear differences between the groups that were not apparent from the clinical scores. Individuals with Parkinson’s disease showed significantly smaller movement amplitude and slower movement speed compared to both the healthy controls and the individuals with REM Sleep Behavior Disorder. They also exhibited a pronounced sequence effect, with both their movement size and speed decreasing over the course of the repetitive taps.

The results for the group with REM Sleep Behavior Disorder were particularly revealing. Unlike the Parkinson’s group, their average movement amplitude and speed were not different from the healthy control group. However, they did show a significant decrement in both amplitude and speed, a pattern similar to what was seen in the Parkinson’s patients. This suggests that the sequence effect, the fatigue-like decline in performance during repetitive movements, may be one of the earliest motor signs of the underlying disease process, appearing even before the classic slowness and smallness of movement associated with a Parkinson’s diagnosis.

To further test the power of these hidden measurements, the researchers used a machine learning algorithm known as a random forest to see if it could accurately classify individuals into their respective groups based only on the four video-derived features. The algorithm performed with high accuracy. It could distinguish people with Parkinson’s disease from healthy controls with 81.5% accuracy.

It could also differentiate individuals with REM Sleep Behavior Disorder from healthy controls with 79.8% accuracy. When tasked with separating the two clinical groups, the model could tell apart individuals with the sleep disorder from those with Parkinson’s disease with 81.7% accuracy. These classification results demonstrate that the subtle, computer-detected features contain enough information to reliably separate the groups, even when they appear identical to a human expert.

The researchers acknowledge certain limitations of their study, most notably the relatively small number of participants. Findings from a smaller sample need to be validated in larger, more diverse groups of people to ensure they are generalizable. Additionally, this work focused exclusively on motor symptoms derived from video. Future research could aim to combine this accessible video analysis with other biological markers, such as those from brain imaging or cerebrospinal fluid, to create an even more powerful and comprehensive tool for predicting who is at risk of developing Parkinson’s disease.

Nevertheless, this study provides evidence that automated video analysis can serve as a sensitive, low-cost, and accessible tool for detecting the earliest signs of neurodegeneration. Such a technology could one day be used for large-scale screening to identify at-risk individuals for inclusion in clinical trials for new neuroprotective therapies, well before more pronounced and life-altering symptoms begin to manifest.

The study, “Video analysis reveals early signs of Bradykinesia in REM sleep behavior disorder and Parkinson’s disease,” was authored by Diego L. Guarín, Gabriela Acevedo, Carolina Calonge, Joshua K. Wong, Nikolaus R. McFarland, Adolfo Ramirez-Zamora, and David E. Vaillancourt.



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Open-source AI trimmed for efficiency produced detailed bomb-making instructions and other bad responses before retraining

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  • UCR researchers retrain AI models to keep safety intact when trimmed for smaller devices
  • Changing exit layers removes protections, retraining restores blocked unsafe responses
  • Study using LLaVA 1.5 showed reduced models refused dangerous prompts after training

Researchers at the University of California, Riverside are addressing the problem of weakened safety in open-source artificial intelligence models when adapted for smaller devices.

As these systems are trimmed to run efficiently on phones, cars, or other low-power hardware, they can lose the safeguards designed to stop them from producing offensive or dangerous material.



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Artificial Intelligence In Capital Markets – Analysis – Eurasia Review

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AI Definition in Capital Markets

By Eva Su and Ling Zhu

The term AI has been defined in federal laws such as the National Artificial Intelligence Initiative Act of 2020 as “a machine-based system that can … make predictions, recommendations or decisions influencing real or virtual environments.” The U.S. capital markets regulator, the Securities and Exchange Commission (SEC), referred to AI in a notice of proposed rulemaking in June 2023 (discussed in more detail below) as a type of predictive data analytics-like technology, describing it as “the capability of a machine to imitate intelligent human behavior.” 

AI Use in Capital Markets

The scope and speed of AI adoption in the financial sector are dependent on both supply-side factors (e.g., technology enablers, data, and business model) and demand-side factors (e.g., revenue or productivity improvements and competitive pressure from peers that are implementing AI tools to obtain market share). Both capital markets industry participants and the SEC may find use for AI as shown below.

Capital Markets Use

Common AI usage in capital markets include (1) investment management and execution, such as investment research, portfolio management, and trading; (2) client support, such as robo-adviser service, chatbots, and other forms of client engagement and underwriting; (3) regulatory compliance, such as anti-money laundering and counter terrorist financing reporting and other compliance processes; and (4) back-office functions, such as internal productivity support and risk management functions.

For example, in its 2023 proposed rule, the SEC observed that some firms and investors in financial markets have used AI technologies, including machine learning and large language model (LLM)-based chatbots, “to make investment decisions and communicate between firms and investors.” LLM is a subset of generative AI that is capable of generating responses to prompts in natural language format once the model has been trained on a large amount of text data. An LLM can have applications in capital markets, such as answering questions and generating computer code. Furthermore, the Financial Industry Regulatory Authority, a self-regulatory organization for broker-dealers under the oversight of the SEC, described some machine learning applications in the securities industry, such as grouping similar trades in a time series of trade events, exploring options pricing and hedging, monitoring large volumes of trading data, keyword extraction from legal documents, and market sentiment analysis.

Regulatory Use

The SEC reported 30 use cases of AI within the agency in its AI Use Case Inventory for 2024. Examples include (1) searching and extracting information from certain securities filings, (2) identifying potentially manipulative trading activities, (3) enhancing the review of public comments, and (4) improving communication and collaboration among the SEC workforce. In 2025, the Office of Management and Budget issued Memorandum M-25-21, providing guidance to agencies (including the SEC) on accelerating AI use and requiring each agency to develop an AI strategy, share certain AI assets, and enable “an AI-ready federal workforce.” 

Selected Policy Issues

While AI offers potential benefits associated with the applications discussed in previous section, its use in capital markets also raises policy concerns. Below are examples of issues relating to AI use in capital markets that Congress may want to consider.

Auditable and explainable capabilities. Advanced AI financial models can produce sophisticated analysis that often may not have outputs explainable to a human. This characteristic has led to concerns about human capability to review and flag potential mistakes and biases embedded in AI analysis. Some financial regulatory authorities have developed AI tools (e.g., Project Noor), to gain more auditability into high-risk financial AI models. 

Accountability. The issue of accountability centers around the question of who bears responsibility when AI systems fail or cause harm. The first known case of an investor suing an AI developer over autonomous trading reportedly occurred in 2019. In that instance, the investor expected the AI to outperform the market and generate substantial returns. Instead, it incurred millions in losses, prompting the investor to seek remedy from the developer.

AI-related information transparency and disclosure. “AI washing“—that is, false and misleading overstatements about AI use—could lead to failures to comply with SEC disclosure requirements. Specifically, certain exaggerated claims that overstate AI usage or AI-related productivity gains may distort the assessments of the investment opportunities and lead to investor harm. The SEC initiated multiple enforcement actions against certain securities offerings and investment advisory servicesthat appeared to have misled investors regarding AI use. 

Concentration and third-party dependency. The substantial costs and specialized expertise required to develop advanced AI models have resulted in a market dominated by a relatively small number of developers and data aggregators, creating concentration risks. This concentration could lead to operational vulnerabilities as disruptions at a few providers could have widespread consequences. Even when financial firms design their own models or rely on in-house data, these tools are typically hosted on third-party cloud providers. Such third-party risks expose participants to vulnerabilities associated with information access, model control, governance, and cybersecurity. 

Market correlation. A common reliance on similar AI models and training data within capital markets may amplify financial fragility. Some observers argue that herding effects—where individual investors make similar decisions based on signals from the same underlying models or data providers—could intensify the interconnectedness of the global financial system, thereby increasing the risk of financial instability.

Collusion. One academic paper indicates that AI systems could collude to fix prices and sideline human traders, potentially undermining market competition and market efficiency. One of its authors explained during an interview that even fairly simple AI algorithms could collude without being prompted, and they could have widespread effects. Others challenged the paper, arguing that AI’s effects on market efficiency is unclear.

Model bias. While AI could overcome certain human biases in investment decisionmaking, it could also introduce and amplify AI bias derived from human programming instructions or training data deficiencies. Such bias could lead to AI systems favoring certain investors over others (e.g., providing more favorable terms or easier access to funding for certain investors based on race, ethnicity or other characteristics) and potentially amplifying inequalities. 

Data. Data is at the core of AI models. Data availability, reliability, infrastructure, security, and privacy are all sources of policy concerns. If an AI system is trained on limited, biased, and non-representative data, it could result in overgeneralization and misinterpretation in capital markets applications.

AI-enabled fraud, manipulation, and cyberattacks. AI could lower the entry barriers for bad actors to distort markets and enable more sophisticated and automated ways to generate fraud and market manipulation. Hackers are reportedly using AI both to distribute malware and deepfake emails targeting financial victims and to develop new types of malicious tools designed to reach and exploit a wider set of targets.

Costs. AI adoption involves significant investments in technology platforms, expenses related to system transitions and business model adjustments, and ongoing operating costs, such as licensing or service fees. For certain large-scale capital markets operations, there is often a lag between initial AI investments and the realization of revenue or productivity gains. As a result, these market participants may face financial pressures when AI spending is not immediately offset by the system’s benefits. Aside from financial impact, some stakeholders are concerned about AI’s environmental costs and the potential costs associated with the transition of the workforce that is displaced by AI.

SEC Actions

In recognition of AI’s transformative potential, the SEC launched an AI task force in August 2025 to enhance innovation in its operations and regulatory oversight. In addition, the SEC has engaged with stakeholders to discuss broader AI issues in capital markets. At an SEC AI roundtable in May 2025, the agency focused on AI-related benefits, costs, and uses; fraud and cybersecurity; and governance and risk management. 

In the June 2023 proposed rulemaking mentioned above, the SEC discussed AI use in capital markets as it sought to address certain conflicts of interest associated with broker-dealers’ or investment advisors’ use of predictive data analytics technologies. The SEC notice was withdrawn in June 2025, along with some other SEC proposed rules introduced during the previous Administration. The SEC has not indicated if AI will be addressed in future rulemaking.

Options for Congress

Some financial authorities and other stakeholders have released reports addressing AI’s capital markets use cases and policy implications. Examples of policy recommendations include to (1) evaluate the adequacy of the current securities regulation in addressing AI-related vulnerabilities; (2) enhance regulatory capabilities by incorporating AI tools into regulatory functions; (3) enhance data monitoring and data collection capabilities; and (4) adopt coordinated approaches to address critical system-wide risks, such as AI third-party provider risks and cyberattack protocols. 

In the 119th Congress, the Unleashing AI Innovation in Financial Services Act (H.R. 4801) would establish regulatory sandboxes—referred to as “AI innovation labs”—at the SEC and other financial regulators. These labs would allow AI test projects to operate with relief from certain regulations and without expectation of enforcement actions. Participating entities would have to apply and gain approval through their primary regulators and demonstrate that the projects serve the public interest, promote investor protection, and do not pose systemic risk. The AI Act of 2024 (H.R. 10262 in the 118th Congress), among other things, would have required the SEC to provide a study on both the realized and potential benefits, risks, and challenges of AI for capital market participants as well as for the agency itself. The study was to incorporate public input through a request for information process and include both regulatory proposals and legislative recommendations.

About the authors:

  • Eva Su, Specialist in Financial Economics
  • Ling Zhu, Analyst in Telecommunications Policy

Source: This article was published at the Congressional Research Service (CRS)



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Ivory Tower: Dr Kamra’s AI research gains UN spotlight

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Dr Preeti Kamra, Assistant Professor in the Department of Computer Science at DAV College, Amritsar, has been invited by the United Nations to address its General Assembly on United Nations Digital Cooperation Day, held during the High-Level Week of the 80th session of the UN General Assembly. An educator and researcher, Dr Kamra has been extensively working in the fields of emerging digital technologies and internet governance.

Holding a PhD in Artificial Intelligence-based technology, Dr Kamra developed AI software to detect anxiety among students and is currently in the process of documenting and patenting this technology under her name. However, it was her work in Internet governance that earned her the invitation to speak at the UN.

“I have been invited to speak at an exclusive, closed-door event hosted annually by the United Nations, United Nations Digital Cooperation Day, which focuses on emerging technologies worldwide. I will be the only Indian speaker at the event and my speech will focus on policies in India aimed at making the Internet more secure, safe, inclusive, and accessible,” Dr Kamra said. “There is a critical need to make the Internet multilingual, accessible and safe in India, especially with the growing use of AI in the future, making timely action imperative.”

Last year, Dr Kamra participated in the Asia-Pacific Regional Forum on Internet Governance held in Taiwan. Her research on AI in education secured her a seat at this prestigious UN event. According to her, AI in education should be promoted, contrary to the reservations many educators globally hold.

“Despite NEP 2020 and the Government of India promoting Artificial Intelligence in higher education, few state-level universities, schools, or colleges have adopted it fully. The key is to use AI productively, which requires laws and policies that regulate its usage, while controlling and monitoring potential abuse,” she explained.

The event is scheduled to take place from September 22 to 26 at the United Nations headquarters in the USA.





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