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Revolutionizing drug data analysis using Amazon Bedrock multimodal RAG capabilities

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In the pharmaceutical industry, biotechnology and healthcare companies face an unprecedented challenge for efficiently managing and analyzing vast amounts of drug-related data from diverse sources. Traditional data analysis methods prove inadequate for processing complex medical documentation that includes a mix of text, images, graphs, and tables. Amazon Bedrock offers features like multimodal retrieval, advanced chunking capabilities, and citations to help organizations get high-accuracy responses.

Pharmaceutical and healthcare organizations process a vast number of complex document formats and unstructured data that pose analytical challenges. Clinical study documents and research papers related to them typically present an intricate blend of technical text, detailed tables, and sophisticated statistical graphs, making automated data extraction particularly challenging. Clinical study documents present additional challenges through non-standardized formatting and varied data presentation styles across multiple research institutions. This post showcases a solution to extract data-driven insights from complex research documents through a sample application with high-accuracy responses. It analyzes clinical trial data, patient outcomes, molecular diagrams, and safety reports from the research documents. It can help pharmaceutical companies accelerate their research process. The solution provides citations from the source documents, reducing hallucinations and enhancing the accuracy of the responses.

Solution overview

The sample application uses Amazon Bedrock to create an intelligent AI assistant that analyzes and summarizes research documents containing text, graphs, and unstructured data. Amazon Bedrock is a fully managed service that offers a choice of industry-leading foundation models (FMs) along with a broad set of capabilities to build generative AI applications, simplifying development with security, privacy, and responsible AI.

To equip FMs with up-to-date and proprietary information, organizations use Retrieval Augmented Generation (RAG), a technique that fetches data from company data sources and enriches the prompt to provide relevant and accurate responses.

Amazon Bedrock Knowledge Bases is a fully managed RAG capability within Amazon Bedrock with in-built session context management and source attribution that helps you implement the entire RAG workflow, from ingestion to retrieval and prompt augmentation, without having to build custom integrations to data sources and manage data flows.

Amazon Bedrock Knowledge Bases introduces powerful document parsing capabilities, including Amazon Bedrock Data Automation powered parsing and FM parsing, revolutionizing how we handle complex documents. Amazon Bedrock Data Automation is a fully managed service that processes multimodal data effectively, without the need to provide additional prompting. The FM option parses multimodal data using an FM. This parser provides the option to customize the default prompt used for data extraction. This advanced feature goes beyond basic text extraction by intelligently breaking down documents into distinct components, including text, tables, images, and metadata, while preserving document structure and context. When working with supported formats like PDF, specialized FMs interpret and extract tabular data, charts, and complex document layouts. Additionally, the service provides advanced chunking strategies like semantic chunking, which intelligently divides text into meaningful segments based on semantic similarity calculated by the embedding model. Unlike traditional syntactic chunking methods, this approach preserves the context and meaning of the content, improving the quality and relevance of information retrieval.

The solution architecture implements these capabilities through a seamless workflow that begins with administrators securely uploading knowledge base documents to an Amazon Simple Storage Service (Amazon S3) bucket. These documents are then ingested into Amazon Bedrock Knowledge Bases, where a large language model (LLM) processes and parses the ingested data. The solution employs semantic chunking to store document embeddings efficiently in Amazon OpenSearch Service for optimized retrieval. The solution features a user-friendly interface built with Streamlit, providing an intuitive chat experience for end-users. When users interact with the Streamlit application, it triggers AWS Lambda functions that handle the requests, retrieving relevant context from the knowledge base and generating appropriate responses. The architecture is secured through AWS Identity and Access Management (IAM), maintaining proper access control throughout the workflow. Amazon Bedrock uses AWS Key Management Service (AWS KMS) to encrypt resources related to your knowledge bases. By default, Amazon Bedrock encrypts this data using an AWS managed key. Optionally, you can encrypt the model artifacts using a customer managed key. This end-to-end solution provides efficient document processing, context-aware information retrieval, and secure user interactions, delivering accurate and comprehensive responses through a seamless chat interface.

The following diagram illustrates the solution architecture.

This solution uses the following additional services and features:

  • The Anthropic Claude 3 family offers Opus, Sonnet, and Haiku models that accept text, image, and video inputs and generate text output. They provide a broad selection of capability, accuracy, speed, and cost operation points. These models understand complex research documents that include charts, graphs, tables, diagrams, and reports.
  • AWS Lambda is a serverless computing service that empowers you to run code without provisioning or managing servers cost effectively.
  • Amazon S3 is a highly scalable, durable, and secure object storage service.
  • Amazon OpenSearch Service is a fully managed search and analytics engine for efficient document retrieval. The OpenSearch Service vector database capabilities enable semantic search, RAG with LLMs, recommendation engines, and search rich media.
  • Streamlit is a faster way to build and share data applications using interactive web-based data applications in pure Python.

Prerequisites

The following prerequisites are needed to proceed with this solution. For this post, we use the us-east-1 AWS Region. For details on available Regions, see Amazon Bedrock endpoints and quotas.

Deploy the solution

Refer to the GitHub repository for the deployment steps listed under the deployment guide section. We use an AWS CloudFormation template to deploy solution resources, including S3 buckets to store the source data and knowledge base data.

Test the sample application

Imagine you are a member of an R&D department for a biotechnology firm, and your job requires you to derive insights from drug- and vaccine-related information from diverse sources like research studies, drug specifications, and industry papers. You are performing research on cancer vaccines and want to gain insights based on cancer research publications. You can upload the documents given in the reference section to the S3 bucket and sync the knowledge base. Let’s explore example interactions that demonstrate the application’s capabilities. The responses generated by the AI assistant are based on the documents uploaded to the S3 bucket connected with the knowledge base. Due to non-deterministic nature of machine learning (ML), your responses might be slightly different from the ones presented in this post.

Understanding historical context

We use the following query: “Create a timeline of major developments in mRNA vaccine technology for cancer treatment based on the information provided in the historical background sections.”The assistant analyzes multiple documents and presents a chronological progression of mRNA vaccine development, including key milestones based on the chunks of information retrieved from the OpenSearch Service vector database.

The following screenshot shows the AI assistant’s response.

RAG Chatbot Assistant

Complex data analysis

We use the following query: “Synthesize the information from the text, figures, and tables to provide a comprehensive overview of the current state and future prospects of therapeutic cancer vaccines.”

The AI assistant is able to provide insights from complex data types, which is enabled by FM parsing, while ingesting the data to OpenSearch Service. It is also able to provide images in the source attribution using the multimodal data capabilities of Amazon Bedrock Knowledge Bases.

The following screenshot shows the AI assistant’s response.

RAG Response 02

The following screenshot shows the visuals provided in the citations when the mouse hovers over the question mark icon.

RAG Response 03

Comparative analysis

We use the following query: “Compare the efficacy and safety profiles of MAGE-A3 and NY-ESO-1 based vaccines as described in the text and any relevant tables or figures.”

The AI assistant used the semantically similar chunks returned from the OpenSearch Service vector database and added this context to the user’s question, which enabled the FM to provide a relevant answer.

The following screenshot shows the AI assistant’s response.

RAG Response 04

Technical deep dive

We use the following query: “Summarize the potential advantages of mRNA vaccines over DNA vaccines for targeting tumor angiogenesis, as described in the review.”

With the semantic chunking feature of the knowledge base, the AI assistant was able to get the relevant context from the OpenSearch Service database with higher accuracy.

The following screenshot shows the AI assistant’s response.

RAG Response 05

The following screenshot shows the diagram that was used for the answer as one of the citations.

RAG Response 06

The sample application demonstrates the following:

  • Accurate interpretation of complex scientific diagrams
  • Precise extraction of data from tables and graphs
  • Context-aware responses that maintain scientific accuracy
  • Source attribution for provided information
  • Ability to synthesize information across multiple documents

This application can help you quickly analyze vast amounts of complex scientific literature, extracting meaningful insights from diverse data types while maintaining accuracy and providing proper attribution to source materials. This is enabled by the advanced features of the knowledge bases, including FM parsing, which aides in interpreting complex scientific diagrams and extraction of data from tables and graphs, semantic chunking, which aides with high-accuracy context-aware responses, and multimodal data capabilities, which aides in providing relevant images as source attribution.

These are some of the many new features added to Amazon Bedrock, empowering you to generate high-accuracy results depending on your use case. To learn more, see New Amazon Bedrock capabilities enhance data processing and retrieval.

Production readiness

The proposed solution accelerates the time to value of the project development process. Solutions built on the AWS Cloud benefit from inherent scalability while maintaining robust security and privacy controls.

The security and privacy framework includes fine-grained user access controls using IAM for both OpenSearch Service and Amazon Bedrock services. In addition, Amazon Bedrock enhances security by providing encryption at rest and in transit, and private networking options using virtual private cloud (VPC) endpoints. Data protection is achieved using KMS keys, and API calls and usage are tracked through Amazon CloudWatch logs and metrics. For specific compliance validation for Amazon Bedrock, see Compliance validation for Amazon Bedrock.

For additional details on moving RAG applications to production, refer to From concept to reality: Navigating the Journey of RAG from proof of concept to production.

Clean up

Complete the following steps to clean up your resources.

  1. Empty the SourceS3Bucket and KnowledgeBaseS3BucketName buckets.
  2. Delete the main CloudFormation stack.

Conclusion

This post demonstrated the powerful multimodal document analysis (text, graphs, images) using advanced parsing and chunking features of Amazon Bedrock Knowledge Bases. By combining the powerful capabilities of Amazon Bedrock FMs, OpenSearch Service, and intelligent chunking strategies through Amazon Bedrock Knowledge Bases, organizations can transform their complex research documents into searchable, actionable insights. The integration of semantic chunking makes sure that document context and relationships are preserved, and the user-friendly Streamlit interface makes the system accessible to end-users through an intuitive chat experience. This solution not only streamlines the process of analyzing research documents, but also demonstrates the practical application of AI/ML technologies in enhancing knowledge discovery and information retrieval. As organizations continue to grapple with increasing volumes of complex documents, this scalable and intelligent system provides a robust framework for extracting maximum value from their document repositories.

Although our demonstration focused on the healthcare industry, the versatility of this technology extends beyond a single industry. RAG on Amazon Bedrock has proven its value across diverse sectors. Notable adopters include global brands like Adidas in retail, Empolis in information management, Fractal Analytics in AI solutions, Georgia Pacific in manufacturing, and Nasdaq in financial services. These examples illustrate the broad applicability and transformative potential of RAG technology across various business domains, highlighting its ability to drive innovation and efficiency in multiple industries.

Refer to the GitHub repo for the agentic RAG application, including samples and components for building agentic RAG solutions. Be on the lookout for additional features and samples in the repository in the coming months.

To learn more about Amazon Bedrock Knowledge Bases, check out the RAG workshop using Amazon Bedrock. Get started with Amazon Bedrock Knowledge Bases, and let us know your thoughts in the comments section.

References

The following are sample research documents available with an open access distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license https://creativecommons.org/licenses/by/4.0/:


About the authors

Vivek Mittal is a Solution Architect at Amazon Web Services, where he helps organizations architect and implement cutting-edge cloud solutions. With a deep passion for Generative AI, Machine Learning, and Serverless technologies, he specializes in helping customers harness these innovations to drive business transformation. He finds particular satisfaction in collaborating with customers to turn their ambitious technological visions into reality.

Sharmika's portraitShamika Ariyawansa, serving as a Senior AI/ML Solutions Architect in the Global Healthcare and Life Sciences division at Amazon Web Services (AWS), has a keen focus on Generative AI. He assists customers in integrating Generative AI into their projects, emphasizing the importance of explainability within their AI-driven initiatives. Beyond his professional commitments, Shamika passionately pursues skiing and off-roading adventures.

Shaik Abdulla is a Sr. Solutions Architect, specializes in architecting enterprise-scale cloud solutions with focus on Analytics, Generative AI and emerging technologies. His technical expertise is validated by his achievement of all 12 AWS certifications and the prestigious Golden jacket recognition. He has a passion to architect and implement innovative cloud solutions that drive business transformation. He speaks at major industry events like AWS re:Invent and regional AWS Summits, where he shares insights on cloud architecture and emerging technologies.



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Books, Courses & Certifications

Complete Guide with Curriculum & Fees

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The year 2025 for AI education provides choices catering to learning style, career goal, and budget. The Logicmojo Advanced Data Science & AI Program has emerged as the top one, offering comprehensive training with proven results in placement for those wishing to pursue job-oriented training. It offers the kind of live training, projects, and career support that fellow professionals seek when interested in turning into a high-paying AI position. 

On the other hand, for the independent learner seeking prestige credentials, a few other good options might include programs from Stanford, MIT, and DeepLearning.AI. Google and IBM certificates are an inexpensive footing for a beginner, while, at the opposite end of the spectrum, a Carnegie Mellon certificate is considered the ultimate academic credential in AI.

Whatever choice you make in 2025 to further your knowledge in AI will place you at the forefront of technology innovation. AI, expected to generate millions of jobs, has the potential to revolutionize every industry, and so whatever you learn today will be the deciding factor in your career waters for at least the next few decades. 



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Artificial Intelligence and Machine Learning Bootcamp Powered by Simplilearn

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Artificial Intelligence and Machine Learning are noteworthy game-changers in today’s digital world. Technological wonders once limited to science fiction have become science fact, giving us innovations such as self-driving cars, intelligent voice-operated virtual assistants, and computers that learn and grow.

The two fields are making inroads into all areas of our lives, including the workplace, showing up in occupations such as Data Scientist and Digital Marketer. And for all the impressive things that Artificial Intelligence and Machine Learning have accomplished in the last ten years, there’s so much more in store.

Become the Highest Paid AI Engineer!

With Our Trending AI Engineer Master ProgramKnow More

Simplilearn wants today’s IT professionals to be better equipped to embrace these new technologies. Hence, it offers Machine Learning Bootcamp, held in conjunction with Caltech’s Center for Technology and Management Education (CTME) and in collaboration with IBM.

The bootcamp covers the relevant points of Artificial Intelligence and Machine Learning, exploring tools and concepts such as Python and TensorFlow. The course optimizes the academic excellence of Caltech and the industry prowess of IBM, creating an unbeatable learning resource that supercharges your skillset and prepares you to navigate the world of AI/ML better.

Why is This a Great Bootcamp?

When you bring together an impressive lineup of Simplilearn, Caltech, and IBM, you expect nothing less than an excellent result. The AI and Machine Learning Bootcamp delivers as promised.

This six-month program deals with vital AI/ML concepts such as Deep Learning, Statistics, and Data Science With Python. Here is a breakdown of the diverse and valuable information the bootcamp offers:

  • Orientation. The orientation session prepares you for the rigors of an intense, six-month learning experience, where you dedicate from five to ten hours a week to learning the latest in AI/ML skills and concepts.
  • Introduction to Artificial Intelligence. There’s a difference between AI and ML, and here’s where you start to learn this. This offering is a beginner course covering the basics of AI and workflows, Deep Learning, Machine Learning, and other details.
  • Python for Data Science. Many data scientists prefer to use the Python programming language when working with AI/ML. This section deals with Python, its libraries, and using a Jupyter-based lab environment to write scripts.
  • Applied Data Science with Python. Your exposure to Python continues with this study of Python’s tools and techniques used for Data Analytics.
  • Machine Learning. Now we come to the other half of the AI/ML partnership. You will learn all about Machine Learning’s chief techniques and concepts, including heuristic aspects, supervised/unsupervised learning, and developing algorithms.
  • Deep Learning with Keras and Tensorflow. This section shows you how to use Keras and TensorFlow frameworks to master Deep Learning models and concepts and prepare Deep Learning algorithms.
  • Advanced Deep Learning and Computer Vision. This advanced course takes Deep Learning to a new level. This module covers topics like Computer Vision for OCR and Object Detection, and Computer Vision Basics with Python.
  • Capstone project. Finally, it’s time to take what you have learned and implement your new AI/ML skills to solve an industry-relevant issue.

Become the Highest Paid AI Engineer!

With Our Trending AI Engineer Master ProgramKnow More

Become the Highest Paid AI Engineer!

The course also offers students a series of electives:

  • Statistics Essentials for Data Science. Statistics are a vital part of Data Science, and this elective teaches you how to make data-driven predictions via statistical inference.
  • NLP and Speech Recognition. This elective covers speech-to-text conversion, text-to-speech conversion, automated speech recognition, voice-assistance devices, and much more.
  • Reinforcement Learning. Learn how to solve reinforcement learning problems by applying different algorithms and strategies like TensorFlow and Python.
  • Caltech Artificial Intelligence and Machine Learning Bootcamp Masterclass. These masterclasses are conducted by qualified Caltech and IBM instructors.

This AI and ML Bootcamp gives students a bounty of AI/ML-related benefits like:

  • Campus immersion, which includes an exclusive visit to Caltech’s robotics lab.
  • A program completion certificate from Caltech CTME.
  • A Caltech CTME Circle membership.
  • The chance to earn up to 22 CEUs courtesy of Caltech CTME.
  • An online convocation by the Caltech CTME Program Director.
  • A physical certificate from Caltech CTME if you request one.
  • Access to hackathons and Ask Me Anything sessions from IBM.
  • More than 25 hands-on projects and integrated labs across industry verticals.
  • A Level Up session by Andrew McAfee, Principal Research Scientist at MIT.
  • Access to Simplilearn’s Career Service, which will help you get noticed by today’s top hiring companies.
  • Industry-certified certificates for IBM courses.
  • Industry masterclasses delivered by IBM.
  • Hackathons from IBM.
  • Ask Me Anything (AMA) sessions held with the IBM leadership.

And these are the skills the course covers, all essential tools for working with today’s AI and ML projects:

  • Statistics
  • Python
  • Supervised Learning
  • Unsupervised Learning
  • Recommendation Systems
  • NLP
  • Neural Networks
  • GANs
  • Deep Learning
  • Reinforcement Learning
  • Speech Recognition
  • Ensemble Learning
  • Computer Vision

About Caltech CTME

Located in California, Caltech is a world-famous, highly respected science and engineering institution featuring some of today’s brightest scientific and technological minds. Contributions from Caltech alumni have earned worldwide acclaim, including over three dozen Nobel prizes. Caltech CTME instructors offer this quality of learning to our students by holding bootcamp master classes.

About IBM

IBM was founded in 1911 and has earned a reputation as the top IT industry leader and master of IT innovation.

How to Thrive in the Brave New World of AI and ML

Machine Learning and Artificial Intelligence have enormous potential to change our world for the better, but the fields need people of skill and vision to help lead the way. Somehow, there must be a balance between technological advancement and how it impacts people (quality of life, carbon footprint, job losses due to automation, etc.).

The AI and Machine Learning Bootcamp helps teach and train students, equipping them to assume a role of leadership in the new world that AI and ML offer.



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Teaching Developers to Think with AI – O’Reilly

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Developers are doing incredible things with AI. Tools like Copilot, ChatGPT, and Claude have rapidly become indispensable for developers, offering unprecedented speed and efficiency in tasks like writing code, debugging tricky behavior, generating tests, and exploring unfamiliar libraries and frameworks. When it works, it’s effective, and it feels incredibly satisfying.

But if you’ve spent any real time coding with AI, you’ve probably hit a point where things stall. You keep refining your prompt and adjusting your approach, but the model keeps generating the same kind of answer, just phrased a little differently each time, and returning slight variations on the same incomplete solution. It feels close, but it’s not getting there. And worse, it’s not clear how to get back on track.

That moment is familiar to a lot of people trying to apply AI in real work. It’s what my recent talk at O’Reilly’s AI Codecon event was all about.

Over the last two years, while working on the latest edition of Head First C#, I’ve been developing a new kind of learning path, one that helps developers get better at both coding and using AI. I call it Sens-AI, and it came out of something I kept seeing:

There’s a learning gap with AI that’s creating real challenges for people who are still building their development skills.

My recent O’Reilly Radar article “Bridging the AI Learning Gap” looked at what happens when developers try to learn AI and coding at the same time. It’s not just a tooling problem—it’s a thinking problem. A lot of developers are figuring things out by trial and error, and it became clear to me that they needed a better way to move from improvising to actually solving problems.

From Vibe Coding to Problem Solving

Ask developers how they use AI, and many will describe a kind of improvisational prompting strategy: Give the model a task, see what it returns, and nudge it toward something better. It can be an effective approach because it’s fast, fluid, and almost effortless when it works.

That pattern is common enough to have a name: vibe coding. It’s a great starting point, and it works because it draws on real prompt engineering fundamentals—iterating, reacting to output, and refining based on feedback. But when something breaks, the code doesn’t behave as expected, or the AI keeps rehashing the same unhelpful answers, it’s not always clear what to try next. That’s when vibe coding starts to fall apart.

Senior developers tend to pick up AI more quickly than junior ones, but that’s not a hard-and-fast rule. I’ve seen brand-new developers pick it up quickly, and I’ve seen experienced ones get stuck. The difference is in what they do next. The people who succeed with AI tend to stop and rethink: They figure out what’s going wrong, step back to look at the problem, and reframe their prompt to give the model something better to work with.

When developers think critically, AI works better. (slide from my May 8, 2025, talk at O’Reilly AI Codecon)

The Sens-AI Framework

As I started working more closely with developers who were using AI tools to try to find ways to help them ramp up more easily, I paid attention to where they were getting stuck, and I started noticing that the pattern of an AI rehashing the same “almost there” suggestions kept coming up in training sessions and real projects. I saw it happen in my own work too. At first it felt like a weird quirk in the model’s behavior, but over time I realized it was a signal: The AI had used up the context I’d given it. The signal tells us that we need a better understanding of the problem, so we can give the model the information it’s missing. That realization was a turning point. Once I started paying attention to those breakdown moments, I began to see the same root cause across many developers’ experiences: not a flaw in the tools but a lack of framing, context, or understanding that the AI couldn’t supply on its own.

The Sens-AI framework steps (slide from my May 8, 2025, talk at O’Reilly AI Codecon)

Over time—and after a lot of testing, iteration, and feedback from developers—I distilled the core of the Sens-AI learning path into five specific habits. They came directly from watching where learners got stuck, what kinds of questions they asked, and what helped them move forward. These habits form a framework that’s the intellectual foundation behind how Head First C# teaches developers to work with AI:

  1. Context: Paying attention to what information you supply to the model, trying to figure out what else it needs to know, and supplying it clearly. This includes code, comments, structure, intent, and anything else that helps the model understand what you’re trying to do.
  2. Research: Actively using AI and external sources to deepen your own understanding of the problem. This means running examples, consulting documentation, and checking references to verify what’s really going on.
  3. Problem framing: Using the information you’ve gathered to define the problem more clearly so the model can respond more usefully. This involves digging deeper into the problem you’re trying to solve, recognizing what the AI still needs to know about it, and shaping your prompt to steer it in a more productive direction—and going back to do more research when you realize that it needs more context.
  4. Refining: Iterating your prompts deliberately. This isn’t about random tweaks; it’s about making targeted changes based on what the model got right and what it missed, and using those results to guide the next step.
  5. Critical thinking: Judging the quality of AI output rather than just simply accepting it. Does the suggestion make sense? Is it correct, relevant, plausible? This habit is especially important because it helps developers avoid the trap of trusting confident-sounding answers that don’t actually work.

These habits let developers get more out of AI while keeping control over the direction of their work.

From Stuck to Solved: Getting Better Results from AI

I’ve watched a lot of developers use tools like Copilot and ChatGPT—during training sessions, in hands-on exercises, and when they’ve asked me directly for help. What stood out to me was how often they assumed the AI had done a bad job. In reality, the prompt just didn’t include the information the model needed to solve the problem. No one had shown them how to supply the right context. That’s what the five Sens-AI habits are designed to address: not by handing developers a checklist but by helping them build a mental model for how to work with AI more effectively.

In my AI Codecon talk, I shared a story about my colleague Luis, a very experienced developer with over three decades of coding experience. He’s a seasoned engineer and an advanced AI user who builds content for training other developers, works with large language models directly, uses sophisticated prompting techniques, and has built AI-based analysis tools.

Luis was building a desktop wrapper for a React app using Tauri, a Rust-based toolkit. He pulled in both Copilot and ChatGPT, cross-checking output, exploring alternatives, and trying different approaches. But the code still wasn’t working.

Each AI suggestion seemed to fix part of the problem but break another part. The model kept offering slightly different versions of the same incomplete solution, never quite resolving the issue. For a while, he vibe-coded through it, adjusting the prompt and trying again to see if a small nudge would help, but the answers kept circling the same spot. Eventually, he realized the AI had run out of context and changed his approach. He stepped back, did some focused research to better understand what the AI was trying (and failing) to do, and applied the same habits I emphasize in the Sens-AI framework.

That shift changed the outcome. Once he understood the pattern the AI was trying to use, he could guide it. He reframed his prompt, added more context, and finally started getting suggestions that worked. The suggestions only started working once Luis gave the model the missing pieces it needed to make sense of the problem.

Applying the Sens-AI Framework: A Real-World Example

Before I developed the Sens-AI framework, I ran into a problem that later became a textbook case for it. I was curious whether COBOL, a decades-old language developed for mainframes that I had never used before but wanted to learn more about, could handle the basic mechanics of an interactive game. So I did some experimental vibe coding to build a simple terminal app that would let the user move an asterisk around the screen using the W/A/S/D keys. It was a weird little side project—I just wanted to see if I could make COBOL do something it was never really meant for, and learn something about it along the way.

The initial AI-generated code compiled and ran just fine, and at first I made some progress. I was able to get it to clear the screen, draw the asterisk in the right place, handle raw keyboard input that didn’t require the user to press Enter, and get past some initial bugs that caused a lot of flickering.

But once I hit a more subtle bug—where ANSI escape codes like ";10H" were printing literally instead of controlling the cursor—ChatGPT got stuck. I’d describe the problem, and it would generate a slightly different version of the same answer each time. One suggestion used different variable names. Another changed the order of operations. A few attempted to reformat the STRING statement. But none of them addressed the root cause.

The COBOL app with a bug, printing a raw escape sequence instead of moving the asterisk.

The pattern was always the same: slight code rewrites that looked plausible but didn’t actually change the behavior. That’s what a rehash loop looks like. The AI wasn’t giving me worse answers—it was just circling, stuck on the same conceptual idea. So I did what many developers do: I assumed the AI just couldn’t answer my question and moved on to another problem.

At the time, I didn’t recognize the rehash loop for what it was. I assumed ChatGPT just didn’t know the answer and gave up. But revisiting the project after developing the Sens-AI framework, I saw the whole exchange in a new light. The rehash loop was a signal that the AI needed more context. It got stuck because I hadn’t told it what it needed to know.

When I started working on the framework, I remembered this old failure and thought it’d be a perfect test case. Now I had a set of steps that I could follow:

  • First, I recognized that the AI had run out of context. The model wasn’t failing randomly—it was repeating itself because it didn’t understand what I was asking it to do.
  • Next, I did some targeted research. I brushed up on ANSI escape codes and started reading the AI’s earlier explanations more carefully. That’s when I noticed a detail I’d skimmed past the first time while vibe coding: When I went back through the AI explanation of the code that it generated, I saw that the PIC ZZ COBOL syntax defines a numeric-edited field. I suspected that could potentially cause it to introduce leading spaces into strings and wondered if that could break an escape sequence.
  • Then I reframed the problem. I opened a new chat and explained what I was trying to build, what I was seeing, and what I suspected. I told the AI I’d noticed it was circling the same solution and treated that as a signal that we were missing something fundamental. I also told it that I’d done some research and had three leads I suspected were related: how COBOL displays multiple items in sequence, how terminal escape codes need to be formatted, and how spacing in numeric fields might be corrupting the output. The prompt didn’t provide answers; it just gave some potential research areas for the AI to investigate. That gave it what it needed to find the additional context it needed to break out of the rehash loop.
  • Once the model was unstuck, I refined my prompt. I asked follow-up questions to clarify exactly what the output should look like and how to construct the strings more reliably. I wasn’t just looking for a fix—I was guiding the model toward a better approach.
  • And most of all, I used critical thinking. I read the answers closely, compared them to what I already knew, and decided what to try based on what actually made sense. The explanation checked out. I implemented the fix, and the program worked.
My prompt that broke ChatGPT out of its rehash loop

Once I took the time to understand the problem—and did just enough research to give the AI a few hints about what context it was missing—I was able to write a prompt that broke ChatGPT out of the rehash loop, and it generated code that did exactly what I needed. The generated code for the working COBOL app is available in this GitHub GIST.

The working COBOL app that moves an asterisk around the screen

Why These Habits Matter for New Developers

I built the Sens-AI learning path in Head First C# around the five habits in the framework. These habits aren’t checklists, scripts, or hard-and-fast rules. They’re ways of thinking that help people use AI more productively—and they don’t require years of experience. I’ve seen new developers pick them up quickly, sometimes faster than seasoned developers who didn’t realize they were stuck in shallow prompting loops.

The key insight into these habits came to me when I was updating the coding exercises in the most recent edition of Head First C#. I test the exercises using AI by pasting the instructions and starter code into tools like ChatGPT and Copilot. If they produce the correct solution, that means I’ve given the model enough information to solve it—which means I’ve given readers enough information too. But if it fails to solve the problem, something’s missing from the exercise instructions.

The process of using AI to test the exercises in the book reminded me of a problem I ran into in the first edition, back in 2007. One exercise kept tripping people up, and after reading a lot of feedback, I realized the problem: I hadn’t given readers all the information they needed to solve it. That helped connect the dots for me. The AI struggles with some coding problems for the same reason the learners were struggling with that exercise—because the context wasn’t there. Writing a good coding exercise and writing a good prompt both depend on understanding what the other side needs to make sense of the problem.

That experience helped me realize that to make developers successful with AI, we need to do more than just teach the basics of prompt engineering. We need to explicitly instill these thinking habits and give developers a way to build them alongside their core coding skills. If we want developers to succeed, we can’t just tell them to “prompt better.” We need to show them how to think with AI.

Where We Go from Here

If AI really is changing how we write software—and I believe it is—then we need to change how we teach it. We’ve made it easy to give people access to the tools. The harder part is helping them develop the habits and judgment to use them well, especially when things go wrong. That’s not just an education problem; it’s also a design problem, a documentation problem, and a tooling problem. Sens-AI is one answer, but it’s just the beginning. We still need clearer examples and better ways to guide, debug, and refine the model’s output. If we teach developers how to think with AI, we can help them become not just code generators but thoughtful engineers who understand what their code is doing and why it matters.



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