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Heart disease and BMI linked with increased breast cancer risk in postmenopausal women

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In postmenopausal women with heart disease, excess weight could be linked to an especially high risk of developing breast cancer, according to international researchers. The team looked at data from over 168,000 postmenopausal women who did not have type 2 diabetes and cardiovascular disease when they agreed to participate. After a follow-up of around 10 years, over 6,000 developed breast cancer, and the team found that in women who developed cardiovascular disease during the study, each 5 point increase in BMI was associated with a 31% higher risk of breast cancer when compared to women without cardiovascular disease.

Journal/conference: CANCER

Research: Paper

Organisation/s: The International Agency for Research on Cancer (IARC), World Health Organization



Funder: Funding was obtained from World Cancer Research Fund (UK), as part of the World Cancer Research Fund International grant program.

Media release

From: Wiley

How does body mass index affect breast cancer risk in postmenopausal women with and without cardiovascular disease?

Analysis shows that weight-associated breast cancer risk is higher in women with cardiovascular disease.

New research reveals that excess weight is linked to an especially high risk of developing breast cancer in postmenopausal women with cardiovascular disease. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.

Although higher body mass index (BMI) is a known risk factor for breast cancer in postmenopausal women, it’s unclear whether this risk differs among women with and without cardiovascular disease or type 2 diabetes. To investigate, a team led by Heinz Freisling, PhD, of the International Agency for Research on Cancer (the specialized cancer agency of the World Health Organization) analyzed data from the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank on 168,547 postmenopausal women who did not have, type 2 diabetes, and cardiovascular disease when they agreed to participate.

After a median follow-up of 10.7 years in EPIC and 10.9 years in UK Biobank, 6,793 postmenopausal women developed breast cancer. In a pooled analysis of both studies, each 5 kg/m2 increase in BMI was associated with a 31% higher risk of breast cancer in women who developed cardiovascular disease during follow-up and a 13% higher risk in women without cardiovascular disease. The development of type 2 diabetes did not seem to affect breast cancer risk: women with or without type 2 diabetes had a similarly elevated breast cancer risk related to higher BMI.

The combination of overweight (BMI≥25 kg/m2) and cardiovascular disease was estimated to lead to 153 more cases of breast cancer per 100,000 people per year than expected.

“The findings of this study could be used to inform risk-stratified breast cancer screening programs,” said Dr. Freisling. “This study should also inspire future research to include women with a history of cardiovascular diseases in weight loss trials for breast cancer prevention.”



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Melting glaciers and ice caps could unleash wave of volcanic eruptions, study says | Climate crisis

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The melting of glaciers and ice caps by the climate crisis could unleash a barrage of explosive volcanic eruptions, a study suggests.

The loss of ice releases the pressure on underground magma chambers and makes eruptions more likely. This process has been seen in Iceland, an unusual island that sits on a mid-ocean tectonic plate boundary. But the research in Chile is one of the first studies to show a surge in volcanism on a continent in the past, after the last ice age ended.

Global heating caused by the burning of fossil fuels is now melting ice caps and glaciers across the world. The biggest risk of a resurgence of volcanic eruptions is in west Antarctica, the researchers said, where at least 100 volcanoes lie under the thick ice. This ice is very likely to be lost in the coming decades and centuries as the world warms.

Volcanic eruptions can cool the planet temporarily by shooting sunlight-reflecting particles into the atmosphere. However, sustained eruptions would pump significant greenhouse gases into the atmosphere, including carbon dioxide and methane. This would further heat the planet and potentially create a vicious circle, in which rising temperatures melt ice that leads to further eruptions and more global heating.

Pablo Moreno-Yaeger, at the University of Wisconsin-Madison, US, who led the research, said: “As glaciers retreat due to climate change, our findings suggest these volcanoes go on to erupt more frequently and more explosively.”

The research, which was presented at the Goldschmidt geochemistry conference in Prague, and is in the final stages of review with an academic journal, involved camping high in the Andes, among active and dormant volcanoes.

Detailed work on one volcano, called Mocho-Choshuenco, used radioisotope dating to estimate the age of volcanic rocks produced before, during and after the last ice age, when the 1,500-metre-thick Patagonian ice sheet covered the area. Analysis of the minerals in the rocks also revealed the depth and temperature at which the rocks formed.

This data revealed that thick ice cover had suppressed the volume of eruptions between 26,000 and 18,000 years ago, allowing a large reservoir of magma to build up 10-15km (6.2-9.3 miles) below the surface. After the ice melted, from about 13,000 years ago, the pressure on the magma chamber was released, gasses in the liquid or molten rock expanded and explosive eruptions followed.

“We found that following deglaciation, the volcano starts to erupt way more, and also changes composition,” said Moreno-Yaeger. The composition changed as the magma melted crustal rocks while eruptions were suppressed. This made the molten rock more viscous and more explosive on eruption.

Iceland has experienced eruptions linked to the melting of its glaciers and ice caps. Photograph: Anadolu/Getty Images

“Our study suggests this phenomenon isn’t limited to Iceland, where increased volcanicity has been observed, but could also occur in Antarctica,” he said. “Other continental regions, like parts of North America, New Zealand and Russia, also now warrant closer scientific attention.”

Previous research has shown volcanic activity increased globally by two to six times after the last ice age, but the Chilean study was one of the first to show how this happened. A similar phenomenon was reported via the analysis of rocks in eastern California in 2004.

A recent review by scientists found there had been relatively little study on how the climate crisis had been affecting volcanic activity. They said more research was “critically important” in order to be better prepared for the damage caused by volcanic eruptions to people and their livelihoods and for possible climate-volcano feedback loops that could amplify the climate crisis. For example, more extreme rainfall is also expected to increase violent explosive eruptions.



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Apple just added more frost to its Liquid Glass design

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Apple’s new Liquid Glass design language just got a little more… frosted. In the third iOS 26 developer beta, Apple dialed back the transparency of navigation bars, buttons, and tabs that once allowed you to clearly see the content beneath them.

Apple already toned down the glassiness of Liquid Glass after many users complained that it was too transparent and made it more difficult to see certain options, like the icons inside the Control Center. This most recent beta makes Liquid Glass elements even more solid, likely as a way to improve readability. Still, some users see the change as a reversal of the flashy, glass-like design that Apple showcased at WWDC.

This is still just a developer beta, so it’s likely that Apple will continue to make tweaks before it releases iOS 26 to the public in September.



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Paolo Banchero signs 5-year max extension with Magic worth up to $287 million

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The Orlando Magic and NBA All-Star Paolo Banchero have agreed on a maximum contract extension that could be worth as much as $287 million over five seasons, according to ESPN’s Shams Charania. The deal includes a player option.

Banchero averaged 25.9 points (on 45/32/73 shooting splits), 7.5 rebounds and 4.8 assists per game this past season, leading the Magic to the first round of the playoffs, where they lost to the defending champion Boston Celtics, 4-1. Banchero averaged a 29-8-4 in that series, looking very much like the franchise player the Magic expected him to be when they drafted him No. 1 overall in 2022.

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An oblique injury this past season limited Banchero to fewer than 65 games, which kept him from All-NBA consideration. That also means he will have to wait until the All-NBA teams are revealed next season to find out if he becomes eligible for a starting salary at 30% of the projected $171.1 million salary cap for the 2026-27 season. Right now, he is eligible for a max extension starting at 25% of that cap.

[Get more Magic news: Orlando team feed]

Either way, the Magic have locked themselves into the maximum possible extensions for both Banchero and Franz Wagner, the foundation of what they believe can be a championship contender. After all, the Magic made their big win-now move during the NBA Finals, trading Kentavious Caldwell-Pope, Cole Anthony and the rights to five first-round draft picks to the Memphis Grizzlies for Desmond Bane.

Bane’s shooting ability (41% on 6.3 3-point attempts per game for his career) should open the floor for Banchero and Wagner, neither of whom has established himself as an elite shooter. They have the potential to become high-end pull-up shooters, which, if that ever happens, watch out for Orlando.

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As is, the Magic allowed 109.1 points per 100 possessions this past season, registering the league’s second-best defensive rating, behind only the NBA champion Oklahoma City Thunder. That head coach Jamahl Mosley has received that kind of buy-in on the defensive end from his young team is a good sign, for if the offense ever catches up to the defense, the Magic could become a serious title contender.

And that is why Banchero is worth every cent of his max contract. He is a key cog in an elite defense and has shown, when healthy, he can be the driver of a top-tier defense, if only he has the horses around him.



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